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Cat. No.: HY-120050

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GK470

GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA₂) with an IC₅₀ of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC₅₀ value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE₂ levels.

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CAS No.: 1621517-53-0
화학식: C₂₁H₂₇NO₄S
분자량:389.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

GK470 Chemical Structure

CAS No.: 1621517-53-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Phospholipase Isoforms :

Chemical Information

CAS No. 1621517-53-0
분자량 389.51
화학식 C₂₁H₂₇NO₄S
SMILES

O=C(OC)C1=CSC(C(COC2=CC=C(C=C2)CCCCCCCC)=O)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kokotos G, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo[J]. Journal of medicinal chemistry, 2014, 57(18): 7523-7535. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
순도&문서
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GK470

All Phospholipase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GK470 Related Classifications

HY-120050 Related Classifications