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Cat. No.: HY-138990

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GK563

GK563 is a selective Ca²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.

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CAS No.: 2351820-19-2
화학식: C₁₆H₂₂O₂
분자량:246.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GK563 Chemical Structure

CAS No.: 2351820-19-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 1 nM (GVIA iPLA2), 22 μM (GVIA cPLA2)^[1]

All Phospholipase Isoforms :

In Vitro

GK563 (0.091 M) inhibits the activity of 100% GVIA iPLA₂, 88% GVIA cPLA₂ and 25% GV sPLA₂^[1].
GK563 (0-0.1 μM) inhibits GVIA iPLA₂ with a X_I(50) value of 0.0000021 and inhibits GVIA cPLA₂ with an IC₅₀ value of 22 μM^[1].
GK563 (0-0.1 μM) shows a better inhibitory effect than fluoroketone FKGK18 to GVIA iPLA₂ with an IC₅₀ value of 1 nM^[1].
GK563 (0-0.1 μM; 16 h) reduces β-cell apoptosis induced by proinflammatory cytokines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

β-cell line
Concentration:

0.1-10 μM
Incubation Time:

16 h
Result:

Promoted a slight but modest rise in cell death when worked alone, but produced a concentration-dependent inhibition of β-cell apoptosis by the co-treatment of cells with cytokines.

Chemical Information

CAS No. 2351820-19-2
분자량 246.34
화학식 C₁₆H₂₂O₂
SMILES

CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dedaki C, et al. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 Mar 28;62(6):2916-2927. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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GK563

All Phospholipase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GK563 Related Classifications

HY-138990 Related Classifications