Hydrocinchonine
Based on 1 Customer Validation
Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp.
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- Purity: 98.33%
- CAS No.: 485-65-4
- 화학식: C19H24N2O
- 분자량:296.41
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Alkaloids Library
HY-L071
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Anti-Cancer Natural Product Library
HY-L107
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Plant-Sourced Natural Product Library
HY-L115
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Human Metabolite Library
HY-L123
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Cancer Stem Cells Compound Library
HY-L135
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Cell Death Library
HY-L162
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Anti-Drug-Resistant Compound Library
HY-L169
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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RO5 Drug-like Natural Product Library
HY-L200
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Mass Spectrometry Human Metabolite Library
HY-L215
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Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
Hydrocinchonine (10 μM, 24 h) potentiates Paclitaxel (TAX)-induced cytotoxicity in P-gp expressing MES-SA (IC50 = 18.59 nM)/DX5 (IC50 = 632.64 nM) cells and shows no significant toxicity to either of the two cell lines at 100 μM[1].
Hydrocinchonine (10 μM, 24 h) effectively makes drug-resistant cancer cells regain sensitivity to apoptosis induced by TAX, leading to a large number of cell deaths in MES-SA/DX5 cells[1].
Hydrocinchonine (10 μM, 1 h) effectively inhibits the function of P-gp, preventing it from pumping the substrate out of the cell, thereby allowing the drugs to accumulate within the MES-SA/DX5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly increased the proportion of Sub-G1 cells with TAX.
Activated Caspase-3 and induced PARP cleavage with combined treatment.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:1 h
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Result:Treated cells exhibited intense green fluorescence, indicating a potent inhibition of P-gp function.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Downregulated the protein expression level of P-gp.
Chemical Information
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CAS No. 485-65-4
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Appearance Solid
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분자량 296.41
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화학식 C19H24N2O
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Color White to off-white
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SMILES
O[C@@H](C1=CC=NC2=C1C=CC=C2)[C@]3([H])[N@@](CC4)C[C@H](CC)[C@]4([H])C3
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Synonyms
Dihydrocinchonine
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
Ethanol : 4 mg/mL (13.49 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (282 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 3.3737 mL | 16.8685 mL | 33.7371 mL | 84.3426 mL |
| 5 mM | 0.6747 mL | 3.3737 mL | 6.7474 mL | 16.8685 mL | |
| 10 mM | 0.3374 mL | 1.6869 mL | 3.3737 mL | 8.4343 mL |
Hydrocinchonine Related Classifications
HY-W035709 Related Classifications
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