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Cat. No.: HY-183565

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HYF031

HYF031 is a selective, blood-brain barrier-permeable HDAC8 inhibitor with an IC₅₀ of 5.7 nM, and exhibits extremely low activity against most other HDAC subtypes. HYF031 is applicable for HDAC8 imaging studies.

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CAS No.: 1417997-91-1
화학식: C₁₆H₁₄BrNO₃
분자량:348.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HYF031 Chemical Structure

CAS No.: 1417997-91-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HDAC8

5.7 nM (IC₅₀)

All HDAC Isoforms :

In Vivo

[¹¹C]HYF031 (5.55-7.40 MBq; intravenous injection; single dose) exhibits detectable brain penetration, pharmacokinetic properties suitable for PET imaging, specific binding to HDAC8 in mouse brains, and is primarily metabolized via the hepatobiliary pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1417997-91-1
분자량 348.19
화학식 C₁₆H₁₄BrNO₃
SMILES

COC1=CC=C(C(C2=CC=C(C=C2)Br)=C1)/C=C/C(NO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. The Development of the Novel Positron Emission Tomography Radiotracer for Selective HDAC8 Imaging. ACS Chem Neurosci. 2026;17(9):1802-1808. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

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HYF031

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HYF031 Related Classifications

HY-183565 Related Classifications