Ilimaquinone
Based on 2 publication(s) in Google Scholar
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects.
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- Purity : 98.0%
- CAS No.: 71678-03-0
- 화학식: C22H30O4
- 분자량:358.47
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ilimaquinone
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
10.9 μM
Compound: 3
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Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 15497946] |
| A549 | IC50 |
0.4 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells after 6 days by MTT assay
Cytotoxicity against human A549 cells after 6 days by MTT assay
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[PMID: 9051909] |
| A549 | IC50 |
5.9 μM
Compound: 14
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Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
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[PMID: 28558970] |
| BV-2 | IC50 |
10.4 μM
Compound: 7
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Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
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[PMID: 28262525] |
| CHO-K1 | GI50 |
2 μM
Compound: 1
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Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay
Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay
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[PMID: 21155589] |
| HeLa | IC50 |
>10 μM
Compound: 1
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
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[PMID: 32040314] |
| HeLa | IC50 |
7.6 μM
Compound: 14
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Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay
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[PMID: 28558970] |
| HT-29 | GI50 |
5.4 μM
Compound: 1
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Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
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[PMID: 21155589] |
| MCF7 | GI50 |
3.9 μM
Compound: 1
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
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[PMID: 21155589] |
| MCF7 | IC50 |
>10 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
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[PMID: 32040314] |
| MCF7 | IC50 |
8.3 μM
Compound: 14
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Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
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[PMID: 28558970] |
| NCI-H460 | GI50 |
1.8 μM
Compound: 1
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Cytotoxicity against human H460 cells after 48 hrs by SRB assay
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
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[PMID: 21155589] |
| P388 | IC50 |
0.2 μg/mL
Compound: 4
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Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
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[PMID: 9051909] |
| PC-3 | IC50 |
>10 μM
Compound: 1
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Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay
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[PMID: 32040314] |
| SF-268 | GI50 |
2.7 μM
Compound: 1
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Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
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[PMID: 21155589] |
| WI-38 | IC50 |
9.7 μM
Compound: 14
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Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
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[PMID: 28558970] |
In Vitro
Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Prostate cancer PC-3 cells
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Concentration:0.3, 1, 3, 10, and 30 μM
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Incubation Time:48 hours
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Result:Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 71678-03-0
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Appearance Solid
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분자량 358.47
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화학식 C22H30O4
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Color Light yellow to brown
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SMILES
C=C1[C@]2(CC[C@@H]([C@](C)([C@@]2(CCC1)[H])CC3=C(C(C=C(C3=O)OC)=O)O)C)C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4. [Abstract]2025 Jul 15;122(28):e2501347122. PMID: 40632561 -
용액&용해도
In Vitro:
DMSO : 25 mg/mL (69.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Pin-Hsuan Lu, et al. Ilimaquinone, a Marine Sponge Metabolite, Displays Anticancer Activity via GADD153-mediated Pathway. Eur J Pharmacol. 2007 Feb 5;556(1-3):45-54. [Content Brief]
[2]. Heebin Son, et al. Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted From a Marine Sponge in Rats. Mar Drugs. 2019 Mar 17;17(3):171. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7896 mL | 13.9482 mL | 27.8963 mL | 69.7408 mL |
| 5 mM | 0.5579 mL | 2.7896 mL | 5.5793 mL | 13.9482 mL | |
| 10 mM | 0.2790 mL | 1.3948 mL | 2.7896 mL | 6.9741 mL | |
| 15 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6494 mL | |
| 20 mM | 0.1395 mL | 0.6974 mL | 1.3948 mL | 3.4870 mL | |
| 25 mM | 0.1116 mL | 0.5579 mL | 1.1159 mL | 2.7896 mL | |
| 30 mM | 0.0930 mL | 0.4649 mL | 0.9299 mL | 2.3247 mL | |
| 40 mM | 0.0697 mL | 0.3487 mL | 0.6974 mL | 1.7435 mL | |
| 50 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3948 mL | |
| 60 mM | 0.0465 mL | 0.2325 mL | 0.4649 mL | 1.1623 mL |
Ilimaquinone Related Classifications
HY-119500 Related Classifications
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