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Cat. No.: HY-116597

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L-783483

(Synonyms: F3MethylAA)

L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice.

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CAS No.: 194608-77-0
화학식: C₂₂H₂₁ClF₃NO₄S
분자량:487.92

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

L-783483 Chemical Structure

CAS No.: 194608-77-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice^[1].

IC₅₀ & Target

PPARδ

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	5900 nM Compound: 1	Activity at LXR alpha as beta-lactamase transactivation in CHO cells Activity at LXR alpha as beta-lactamase transactivation in CHO cells	[PMID: 16529931]
CHO	EC₅₀	7300 nM Compound: 1	Activity at LXR beta as beta-lactamase transactivation in CHO cells Activity at LXR beta as beta-lactamase transactivation in CHO cells	[PMID: 16529931]
HEK293	EC₅₀	1080 nM Compound: 1	Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay	[PMID: 15911262]
HEK293	EC₅₀	1790 nM Compound: 1	Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay	[PMID: 15911262]

Chemical Information

CAS No. 194608-77-0
분자량 487.92
화학식 C₂₂H₂₁ClF₃NO₄S
SMILES

O=C(CC1=CC=C(C(Cl)=C1)SCCCOC2=C(CCC)C(ON=C3C(F)(F)F)=C3C=C2)O
Synonyms

F3MethylAA
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wan YJ, et al., Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha. PPAR Res. 2006;2006:96341. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

L-783483

All PPAR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

L-783483 Related Classifications

HY-116597 Related Classifications