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Cat. No.: HY-123654

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L-796449

L-796449 is a potent PPARγ agonist. L-796449 shows neuroprotective. L-796449 has the potential for the research of stroke.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 194608-80-5
화학식: C₂₈H₂₇ClO₄S
분자량:495.03

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

L-796449 Chemical Structure

CAS No.: 194608-80-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

L-796449 is a potent PPARγ agonist. L-796449 shows neuroprotective. L-796449 has the potential for the research of stroke^[1].

IC₅₀ & Target

PPARγ^[1]

All PPAR Isoforms :

In Vivo

L-796449 (1 mg/kg; i.p.) shows neuroprotective in middle cerebral artery occlusion (MCAO) in the rat brain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

250 g adult male Fischer rats^[1]
Dosage:

1 mg/kg (MCAO 10 minutes before IP injection)
Administration:

I.p.
Result:

Decreased MCAO-induced infarct size determined 2 and 7 days after the ischemic injury, inhibited MCAO-induced expression of iNOS and MMP-9 but did not affect COX-2 levels at the time examined; increased the expression of heme oxygenase-1 (HO-1) and inhibited NF-κB signaling.

Chemical Information

CAS No. 194608-80-5
분자량 495.03
화학식 C₂₈H₂₇ClO₄S
SMILES

O=C(CC1=CC=C(C(Cl)=C1)SCCCOC2=C(C3=C(C(C4=CC=CC=C4)=CO3)C=C2)CCC)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pereira MP, et al. The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke. J Neuropathol Exp Neurol. 2005 Sep;64(9):797-805. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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L-796449

All PPAR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

L-796449 Related Classifications

HY-123654 Related Classifications