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Cat. No.: HY-189677

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LF39

LF39 is a STAT3/TrxR1 inhibitor (TrxR IC₅₀ = 0.515 μM). LF39 induces Apoptosis and ROS accumulation. LF39 exhibits selective anticancer activity against colorectal cancer. LF39 can be used for research on colorectal cancer.

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화학식: C₂₆H₂₂N₂O₄
분자량:426.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LF39 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

STAT3

TrxR1

0.515 μM (IC₅₀)

All STAT Isoforms :

All TrxR Isoforms :

TrxR1
TrxR2

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	0.48 μM	Antiproliferative activity against human HCT116 colorectal cancer cells. Antiproliferative activity against human HCT116 colorectal cancer cells.	42722114
HT-29	IC50	0.55 μM	Antiproliferative activity against human HT-29 colorectal cancer cells. Antiproliferative activity against human HT-29 colorectal cancer cells.	42722114
SW480	IC50	1.332 μM	Antiproliferative activity against human SW480 colorectal cancer cells. Antiproliferative activity against human SW480 colorectal cancer cells.	42722114
LoVo	IC50	0.668 μM	Antiproliferative activity against human LoVo colorectal cancer cells. Antiproliferative activity against human LoVo colorectal cancer cells.	42722114
NCM460	IC50	1.968 μM	Cytotoxicity against normal human NCM460 colon mucosal epithelial cells. Cytotoxicity against normal human NCM460 colon mucosal epithelial cells.	42722114

In Vitro

Anti-cancerOxidative StressApoptosisOthers

Anti-cancer

LF39 exhibits potent antiproliferative activity against HCT116 (IC₅₀ = 0.48 μM) and HT-29 (IC₅₀ = 0.55 μM) colorectal cancer cells^[1].
LF39 preferentially inhibited CRC cells SW480 and LoVo (IC₅₀ = 1.332 and 0.668 μM), while showing weaker effects on normal NCM460 cells (IC₅₀ = 1.968 μM)^[1].
LF39 (0.625-5 μM) inhibits p-STAT3 (Tyr705) in HCT116 cells in a dose-dependent manner without affecting total STAT3^[1].

Oxidative Stress

Anti-cancer

LF39 (0.625-1.25 μM; 2 h) induced dose-dependent intracellular ROS accumulation in HCT116 cells, with a massive oxidative burst occurring at 1.25 μM^[1].

Apoptosis

Anti-cancer

LF39 (1.25-20 μM; 48 h) induces dose-dependent apoptosis in HCT116 cells^[1].

Others

LF39 (IC₅₀ = 0.515 μM) inhibits TrxR enzyme activity in cell-free assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HCT116
Concentration:

1.25, 2.5, 5, 10, 20 μM
Incubation Time:

48 h
Result:

Significantly increased the proportion of apoptotic cells.

Related Protocols :

Chemical Information

분자량 426.46
화학식 C₂₆H₂₂N₂O₄
SMILES

CN1CCN(CC1)C2=CC=C(C=C2)/C=C/C(C3=CC4=C(O3)C(C5=CC=CC=C5C4=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of novel dual STAT3/TrxR1 inhibitors via pharmacophore fusion as potent lead compounds for colorectal cancer. Bioorganic & medicinal chemistry letters. 2026 Sep 10;142:130777.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

LF39

All STAT Isoforms

All TrxR Isoforms