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United States

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Cat. No.: HY-176067

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LO-4-25

LO-4-25 is a CUL4^DCAF16 based covalent PROTAC-like degrader. LO-4-25 induces degradation of the androgen receptor (AR) and androgen receptor truncation variant AR-V7. LO-4-25 covalently targets cysteine residues on CUL4^DCAF16 to mediate degradation of neo-substrates. LO-4-25 triggers proteasome-dependent degradation of target proteins via CUL4^DCAF16-mediated ubiquitination. LO-4-25 can be used for the research of androgen-independent prostate cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₂H₃₇ClN₆O₅S
분자량:653.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

LO-4-25 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PROTACs Isoforms :

In Vitro

LO-4-25 (1-10 μM; 24 h) potently degrades both AR and AR-V7 in 22Rv1 cells in a CUL4_DCAF16-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

22Rv1 androgen-independent prostate cancer cells
Concentration:

1 μM, 10 μM
Incubation Time:

24 h
Result:

Induced robust degradation of both AR and AR-V7 in 22Rv1 cells.
Completely attenuated degradation of AR and AR-V7 in 22Rv1 cells with DCAF16 knockdown via siRNA transfection.

Chemical Information

분자량 653.19
화학식 C₃₂H₃₇ClN₆O₅S
SMILES

O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(CC2)C(CCCCCOC3=CC=C(C=C3)C4=CSC(N5CCOCC5)=N4)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Orr LM, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. ACS central science. 2025 Jul 23;11(7):1207-1217. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

LO-4-25

All PROTACs Isoforms