LT-104A
LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research.
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- CAS No.: 2574572-03-3
- 화학식: C33H34O7
- 분자량:542.62
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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PDE4D3 9.3 μM (IC50) |
In Vitro
LT-104A (1-30 μM; 24 h) reduces LPS (HY-D1056) -induced Il1b and Nos2 mRNA expression in J774A.1 macrophages[1].
LT-104A (1-30 μM; 24 h) decreases LPS -induced nitric oxide production in J774A.1 macrophages[1].
LT-104A (0.1-30μM; 30 min) increases intracellular cAMP levels in HEK293 cells in a concentration-dependent manner (EC50 = 1.9 μM)[1].
LT-104A (0.1-30 μM; 6 h) enhances CRE-luciferase activity through activation of the cAMP-PKA-CREB signaling pathway in HEK293 cells[1].
LT-104A (0.1-100 μM) inhibits recombinant PDE4D3 enzymatic activity with an IC50 of 9.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS(1 μg/mL, 24 h)induced J774A.1 macrophages
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Concentration:1 , 3 , 10 , 30 μM
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Incubation Time:30 min before LPS treatment for 24 h.
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Result:Reduced LPS-induced Il1b and Nos2 mRNA expression.
Chemical Information
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CAS No. 2574572-03-3
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분자량 542.62
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화학식 C33H34O7
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SMILES
O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LT-104A Related Classifications
HY-179407 Related Classifications
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