Metyrosine
Based on 1 Customer Validation
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
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- Purity: 99.29%
- CAS No.: 672-87-7
- 화학식: C10H13NO3
- 분자량:195.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
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Dosage:50, 100 or 200 mg/kg
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Administration:I.p.
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Result:Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 672-87-7
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Appearance Solid
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분자량 195.22
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화학식 C10H13NO3
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Color White to off-white
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SMILES
C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
용액&용해도
1 M HCl : 50 mg/mL (256.12 mM; Need ultrasonic)
H2O : 5 mg/mL (25.61 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [Content Brief]
[2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / 1 M HCl | 1 mM | 5.1225 mL | 25.6124 mL | 51.2248 mL | 128.0620 mL |
| 5 mM | 1.0245 mL | 5.1225 mL | 10.2450 mL | 25.6124 mL | |
| 10 mM | 0.5122 mL | 2.5612 mL | 5.1225 mL | 12.8062 mL | |
| 15 mM | 0.3415 mL | 1.7075 mL | 3.4150 mL | 8.5375 mL | |
| 20 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4031 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0490 mL | 5.1225 mL | |
| 1 M HCl | 30 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL |
| 40 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 50 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 60 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1344 mL | |
| 80 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 100 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Metyrosine Related Classifications
HY-W015007 Related Classifications
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