MIPS3526
MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver.
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- 화학식: C44H43F3N10O5S
- 분자량:880.94
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
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A2BR 10.24 (pEC50) |
A2BR 58 pM (EC50) |
A1AR 7.08 (pEC50) |
A2AR 6.72 (pEC50) |
A3R 5.48 (pEC50) |
MIPS3526 (compound 7; 1-10 μM) ameliorates angiotensin II-induced neonatal rat cardiomyocyte (NCM) hypertrophywas[1].
\r\nMIPS3526 (1-10 μM) attenuates TGFβ-stimulated collagen synthesis in cardiac fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 880.94
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화학식 C44H43F3N10O5S
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SMILES
NC(S1)=C(C(C2=CC=CC=C2)=O)C(C3=CC(C(F)(F)F)=CC=C3)=C1C(C=C4)=CC=C4C(N=N5)=CN5CCCCCCNC6=NC=NC7=C6N=CN7[C@@H]8O[C@H](C(NCC)=O)[C@@H](O)[C@H]8O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MIPS3526 Related Classifications
HY-179277 Related Classifications
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