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Cat. No.: HY-117693

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(E/Z)-Mirin

Name: (E/Z)-Mirin
Brand: MedChemExpress
SKU: HY-117693
Price: 50.00 USD
Availability: InStock
Rating: 5 (10 reviews)

10 Cited Publications

고객리뷰

Based on 10 publication(s) in Google Scholar

(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.22%
CAS No.: 299953-00-7
화학식: C₁₀H₈N₂O₂S
분자량:220.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E/Z)-Mirin Chemical Structure

CAS No.: 299953-00-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
Publications (10)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All ATM/ATR Isoforms :

In Vitro

Mirin inhibits H2AX phosphorylation with an IC₅₀ of 66 μM. Mirin also inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2, as well as MRN-dependent autophosphorylation of ATM at Ser1981 in DSB reactions. Mirin at concentrations of 50 μM and 100 μM induces significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells^[1].
BRCA2-deficient cells also show hypersensitivity to the Mre11 inhibitor Mirin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 299953-00-7
Appearance Solid
분자량 220.25
화학식 C₁₀H₈N₂O₂S
Color Yellow to orange
SMILES

O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (10)

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Cell Stem Cell

Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity. [Abstract]

2026 Mar 5;33(3):470-486.e14. PMID: 41742419

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]

ΔATAC profile of editing loci Emx1 (left) and Tyr (right) under different concentrations of (E/Z)-Mirin (25-200 μM) in NIH3T3 cells.

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]

(E/Z)-Mirin (50 μM; 2 d) reduced the genome-editing-induced stem cell loss without compromising editing efficiency.
Nat Cell Biol

Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks. [Abstract]

2025 Jun;27(6):992-1005. PMID: 40447771

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Jun;27(6):992-1005. [Abstract]

(E/Z)-Mirin (100 μM; 1 h) decreased RNA:DNA hybrids at DSBs.
Nat Chem Biol

Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51. [Abstract]

2025 Aug;21(8):1182-1193. PMID: 39809895
Nucleic Acids Res

Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining. [Abstract]

2025 Mar 20;53(6):gkaf200. PMID: 40114375
Adv Sci (Weinh)

The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability. [Abstract]

2024 Aug;11(30):e2307751. PMID: 38894550

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Aug;11(30):e2307751. [Abstract]

MRE11 inhibitor (E/Z)-Mirin (50 µM; 4 h) alleviated HU-induced genomic instability in prelamin A-expressing cells.
Mol Cancer Ther

2026 Jul 15:10.1158/1535-7163.MCT-26-0182. PMID: 42456172
PLoS Pathog

Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome. [Abstract]

2025 Jan 3;21(1):e1012824. PMID: 39752632

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2025 Jan 3;21(1):e1012824. [Abstract]

(E/Z)-Mirin (25-50 μM; 5 d) decreased the levels of HBeAg in HepG2-NTCP-K7 cells in a dose-dependent manner.
bioRxiv

2025 Aug 21.
bioRxiv

Oncogene Silencing via ecDNA Micronucleation. [Abstract]

2025 Apr 18:2025.04.15.648906. PMID: 40321211
bioRxiv

2023: 2023.11

용액&용해도

In Vitro:

DMSO : 83.33 mg/mL (378.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5403 mL

22.7015 mL

45.4030 mL

5 mM

0.9081 mL

4.5403 mL

9.0806 mL

10 mM

0.4540 mL

2.2701 mL

4.5403 mL

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4(2):119-125. [Content Brief]

[2]. Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72(11):2814-2821. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.5403 mL	22.7015 mL	45.4030 mL	113.5074 mL
	5 mM	0.9081 mL	4.5403 mL	9.0806 mL	22.7015 mL
	10 mM	0.4540 mL	2.2701 mL	4.5403 mL	11.3507 mL
	15 mM	0.3027 mL	1.5134 mL	3.0269 mL	7.5672 mL
	20 mM	0.2270 mL	1.1351 mL	2.2701 mL	5.6754 mL
	25 mM	0.1816 mL	0.9081 mL	1.8161 mL	4.5403 mL
	30 mM	0.1513 mL	0.7567 mL	1.5134 mL	3.7836 mL
	40 mM	0.1135 mL	0.5675 mL	1.1351 mL	2.8377 mL
	50 mM	0.0908 mL	0.4540 mL	0.9081 mL	2.2701 mL
	60 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8918 mL
	80 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.4188 mL
	100 mM	0.0454 mL	0.2270 mL	0.4540 mL	1.1351 mL

Bioz

Keywords

(E/Z)-Mirin

10 Cited Publications

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
Publications (10)
용액&용해도
- In Vitro
순도&문서
References

1/16
1/16

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]

Customer Validation
ΔATAC profile of editing loci Emx1 (left) and Tyr (right) under different concentrations of (E/Z)-Mirin (25-200 μM) in NIH3T3 cells.
1/16

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]

Customer Validation
(E/Z)-Mirin (50 μM; 2 d) reduced the genome-editing-induced stem cell loss without compromising editing efficiency.
1/16

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Jun;27(6):992-1005. [Abstract]

Customer Validation
(E/Z)-Mirin (100 μM; 1 h) decreased RNA:DNA hybrids at DSBs.
1/16

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2025 Jan 3;21(1):e1012824. [Abstract]

Customer Validation
(E/Z)-Mirin (25-50 μM; 5 d) decreased the levels of HBeAg in HepG2-NTCP-K7 cells in a dose-dependent manner.
1/16

(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Aug;11(30):e2307751. [Abstract]

Customer Validation
MRE11 inhibitor (E/Z)-Mirin (50 µM; 4 h) alleviated HU-induced genomic instability in prelamin A-expressing cells.

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(E/Z)-Mirin

Publications Citing Use of MedChemExpress (MCE) (E/Z)-Mirin

All ATM/ATR Isoforms