(E/Z)-Mirin
Based on 9 publication(s) in Google Scholar
(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.22%
- CAS No.: 299953-00-7
- 화학식: C10H8N2O2S
- 분자량:220.25
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) (E/Z)-Mirin
More- Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]
- Nat Cell Biol. 2025 Jun;27(6):992-1005. [Abstract]
- Nat Chem Biol. 2025 Aug;21(8):1182-1193. [Abstract]
- Nucleic Acids Res. 2025 Mar 20;53(6):gkaf200. [Abstract]
- Adv Sci (Weinh). 2024 Jun 18:e2307751. [Abstract]
- PLoS Pathog. 2025 Jan 3;21(1):e1012824. [Abstract]
- bioRxiv. 2025 Aug 21.
- bioRxiv. 2025 Apr 18:2025.04.15.648906. [Abstract]
- bioRxiv. 2023: 2023.11
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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ELISA
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Bio/Physico-chemical Assay
Biological Activity
Mirin inhibits H2AX phosphorylation with an IC50 of 66 μM. Mirin also inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2, as well as MRN-dependent autophosphorylation of ATM at Ser1981 in DSB reactions. Mirin at concentrations of 50 μM and 100 μM induces significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells[1].
BRCA2-deficient cells also show hypersensitivity to the Mre11 inhibitor Mirin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 299953-00-7
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Appearance Solid
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분자량 220.25
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화학식 C10H8N2O2S
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Color Yellow to orange
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SMILES
O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity. [Abstract]2026 Mar 5;33(3):470-486.e14. PMID: 41742419
(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]
ΔATAC profile of editing loci Emx1 (left) and Tyr (right) under different concentrations of (E/Z)-Mirin (25-200 μM) in NIH3T3 cells.
(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14. [Abstract]
(E/Z)-Mirin (50 μM; 2 d) reduced the genome-editing-induced stem cell loss without compromising editing efficiency.
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Nat Cell Biol
Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks. [Abstract]2025 Jun;27(6):992-1005. PMID: 40447771
(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Jun;27(6):992-1005. [Abstract]
(E/Z)-Mirin (100 μM; 1 h) decreased RNA:DNA hybrids at DSBs.
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Nat Chem Biol
2025 Aug;21(8):1182-1193. PMID: 39809895 -
Nucleic Acids Res
Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining. [Abstract]2025 Mar 20;53(6):gkaf200. PMID: 40114375 -
Adv Sci (Weinh)
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability. [Abstract]2024 Jun 18:e2307751. PMID: 38894550
(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 18:e2307751. [Abstract]
MRE11 inhibitor (E/Z)-Mirin (50 µM; 4 h) alleviated HU-induced genomic instability in prelamin A-expressing cells.
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PLoS Pathog
2025 Jan 3;21(1):e1012824. PMID: 39752632
(E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2025 Jan 3;21(1):e1012824. [Abstract]
(E/Z)-Mirin (25-50 μM; 5 d) decreased the levels of HBeAg in HepG2-NTCP-K7 cells in a dose-dependent manner.
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bioRxiv
2025 Apr 18:2025.04.15.648906. PMID: 40321211 -
용액&용해도
DMSO : 83.33 mg/mL (378.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4(2):119-125. [Content Brief]
[2]. Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72(11):2814-2821. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5403 mL | 22.7015 mL | 45.4030 mL | 113.5074 mL |
| 5 mM | 0.9081 mL | 4.5403 mL | 9.0806 mL | 22.7015 mL | |
| 10 mM | 0.4540 mL | 2.2701 mL | 4.5403 mL | 11.3507 mL | |
| 15 mM | 0.3027 mL | 1.5134 mL | 3.0269 mL | 7.5672 mL | |
| 20 mM | 0.2270 mL | 1.1351 mL | 2.2701 mL | 5.6754 mL | |
| 25 mM | 0.1816 mL | 0.9081 mL | 1.8161 mL | 4.5403 mL | |
| 30 mM | 0.1513 mL | 0.7567 mL | 1.5134 mL | 3.7836 mL | |
| 40 mM | 0.1135 mL | 0.5675 mL | 1.1351 mL | 2.8377 mL | |
| 50 mM | 0.0908 mL | 0.4540 mL | 0.9081 mL | 2.2701 mL | |
| 60 mM | 0.0757 mL | 0.3784 mL | 0.7567 mL | 1.8918 mL | |
| 80 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.4188 mL | |
| 100 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1351 mL |
(E/Z)-Mirin Related Classifications
HY-117693 Related Classifications
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