MU380
Based on 1 Customer Validation
MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity.
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- Purity : 99.6%
- CAS No.: 2109805-78-7
- 화학식: C15H15BrF3N7
- 분자량:430.23
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
MU380 (100 nM, 24 h) potently inhibits CHK1 kinase and sensitizes lymphoid tumor cells to gemcitabine[1].
MU380 (400 nM, 24 h) can significantly affect the cell cycle profile and induce the death of dividing and non-dividing primary chronic lymphocytic leukemia lymphocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MEC-1and MEC-2 cells
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Concentration:400 nM
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Incubation Time:24 h
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Result:Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).
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Cell Line:Chronic lymphocytic leukemia cells
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Concentration:100 nM or 200 nM
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Incubation Time:24 h
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Result:Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD-scid IL2Rγnull mice[1]
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Dosage:20 mg/kg
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Administration:In 20% aqueous Kolliphor solution, every three days from day 14 to day 28
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Result:Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.
Chemical Information
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CAS No. 2109805-78-7
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Appearance Solid
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분자량 430.23
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화학식 C15H15BrF3N7
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Color White to off-white
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SMILES
NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C(F)(F)F)N=C4)C=NN13
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MU380 Related Classifications
HY-112927 Related Classifications
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