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Cat. No.: HY-175812

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MU876

Name: MU876
Brand: MedChemExpress
SKU: HY-175812
Price: 800.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

MU876 is a MUS81 inhibitor (IC₅₀ 0.52 μM). MU876 inhibits Endonuclease activity and disrupts its binding to branched DNA substrates. MU876 inhibits homologous recombination and break-induced replication DNA repair without affecting non-homologous end joining. MU876 induces the accumulation of micronuclei, telomere-free chromosome ends, and DNA damage foci. MU876 sensitizes cancer cells to the cytotoxicity of Cisplatin (HY-17394). MU876 does not induce apoptosis after short-term exposure, nor does it significantly perturb cell cycle distribution at low concentrations.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 97.00%
CAS No.: 1208829-24-6
화학식: C₂₄H₁₈N₆O₃
분자량:438.44

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MU876 Chemical Structure

CAS No.: 1208829-24-6

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC50	0.24 μM	Inhibition of break-induced replication by MU876 in U2OS BIR-GFP reporter cells assessed as reduction in GFP-positive cells by flow cytometry 72 hrs after I-SceI transfection. Inhibition of break-induced replication by MU876 in U2OS BIR-GFP reporter cells assessed as reduction in GFP-positive cells by flow cytometry 72 hrs after I-SceI transfection.	41740057
U2OS	IC50	0.5-1 μM	Inhibition of homologous recombination by MU876 in U2OS DR-GFP reporter cells assessed as reduction in GFP-positive cells by flow cytometry 72 hrs after I-SceI transfection. Inhibition of homologous recombination by MU876 in U2OS DR-GFP reporter cells assessed as reduction in GFP-positive cells by flow cytometry 72 hrs after I-SceI transfection.	41740057

In Vitro

ApoptosisCell Cycle RegulationOthers

Apoptosis

Cell Cycle Regulation

MU876 (0.5-1 μM; 72 hours) does not induce apoptosis in U2OS WT cells within 72 hours and only mildly increases S-phase cells at 1 μM, whereas 0.5 μM has no significant effect on cell cycle distribution^[1].

Others

MU876 (0.05-3.1 μM) inhibits purified MUS81-EME1 3′ flap cleavage with an IC₅₀ of 0.52 μM^[1].
MU876 inhibits BIR in U2OS BIR-GFP cells with an IC₅₀ of 0.24 μM, and inhibits HR with an IC₅₀ of 0.5-1 μM, without impairing NHEJ^[1].
MU876 (0.25-0.5 μM; twice weekly for nearly 3 weeks) inhibits the proliferation of CAL51 WT cells over nearly three weeks^[1].
MU876 (3-12 μM; 48 h) increases micronucleus formation in U2OS cells^[1].
MU876 (72 hours) increases γH2AX foci in U2OS cells after 72 hours^[1].
MU876 (maximum concentration 1 μM, 2-fold serial dilution) reduces clonogenic survival of U2OS cells^[1].
MU876 enhances Cisplatin (HY-17394)-induced loss of viability in U2OS, HEK293, and CAL51 WT cells, but has no such effect on CAL51 MUS81^−/− cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

CAL51 WT cells
Concentration:

0.25 and 0.5 μM
Incubation Time:

twice weekly for almost 3 weeks
Result:

Strongly suppressed proliferation at 0.25 and 0.5 μM.

Related Protocols :

Chemical Information

CAS No. 1208829-24-6
Appearance Solid
분자량 438.44
화학식 C₂₄H₁₈N₆O₃
Color White to off-white
SMILES

O=C(C1=NOC(C2=CC=CC=C2)=C1)NC3=CC(C4=CC=CC=C4)=NN3C5=NC(C)=CC(N5)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prochazkova J, et al. Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells. Journal of medicinal chemistry. 2026 Mar 12;69(5):5350-5369. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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