NLRP3 modulator 7
NLRP3 modulator 7 (Compound 17B) is a NLRP3 inflammasome modulator. NLRP3 modulator 7 inhibits LPS (HY-D1056)-induced IL-1β release in fresh human whole blood. NLRP3 modulator 7 can be used in studies related to NLRP3 inflammasome activation and innate immune signaling.
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- Purity: 99.31%
- CAS No.: 2982797-42-0
- 화학식: C19H22F3N3O2
- 분자량:381.39
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
NLRP3 inflammasome |
IL-1b < 500 nM (IC50) |
In Vitro
NLRP3 modulator 7 (Compound 17B) inhibits IL-1β production in immune cells stimulated via NLRP3 inflammasome activation with an IC50 < 500 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2982797-42-0
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Appearance Solid
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분자량 381.39
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화학식 C19H22F3N3O2
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Color White to off-white
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SMILES
OC1=C(C2=C(C=C(N=N2)[C@@H]([C@@]3([H])CN(CCC3)C)O)C)C=CC(C(F)(F)F)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (262.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6220 mL | 13.1099 mL | 26.2199 mL | 65.5497 mL |
| 5 mM | 0.5244 mL | 2.6220 mL | 5.2440 mL | 13.1099 mL | |
| 10 mM | 0.2622 mL | 1.3110 mL | 2.6220 mL | 6.5550 mL | |
| 15 mM | 0.1748 mL | 0.8740 mL | 1.7480 mL | 4.3700 mL | |
| 20 mM | 0.1311 mL | 0.6555 mL | 1.3110 mL | 3.2775 mL | |
| 25 mM | 0.1049 mL | 0.5244 mL | 1.0488 mL | 2.6220 mL | |
| 30 mM | 0.0874 mL | 0.4370 mL | 0.8740 mL | 2.1850 mL | |
| 40 mM | 0.0655 mL | 0.3277 mL | 0.6555 mL | 1.6387 mL | |
| 50 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL | 1.3110 mL | |
| 60 mM | 0.0437 mL | 0.2185 mL | 0.4370 mL | 1.0925 mL | |
| 80 mM | 0.0328 mL | 0.1639 mL | 0.3277 mL | 0.8194 mL | |
| 100 mM | 0.0262 mL | 0.1311 mL | 0.2622 mL | 0.6555 mL |
NLRP3 modulator 7 Related Classifications
HY-160757 Related Classifications
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