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Cat. No.: HY-123795

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NY0123

NY0123 is a EPAC1 inhibitor. NY0123 significantly inhibits the expression of EPAC1, phosphorylated AKT, phosphorylated ERK1/2 and phosphorylated VEGFR2. NY0123 inhibits angiogenesis and tumor growth of triple-negative breast cancer. NY0123 is applicable to relevant research on triple-negative breast cancer.

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CAS No.: 1801911-70-5
화학식: C₁₆H₁₃Cl₃N₄O₂
분자량:399.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NY0123 Chemical Structure

CAS No.: 1801911-70-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

VEGFR2

ERK1

ERK2

EPAC1

All Ras Isoforms :

All Akt Isoforms :

All ERK Isoforms :

All VEGFR Isoforms :

In Vivo

NY0123 (10 mg/kg; i.p.; every two days; 14 days) significantly suppresses triple-negative breast cancer tumor growth, angiogenesis, and cell proliferation in BALB/c mice with greater efficacy than ESI-09 and no observed organ toxicity^[1].
NY0123 (25-100 μM; topical application to CAM; single dose; 48-hour incubation) significantly suppresses angiogenesis in Gallus gallus domesticus embryo CAM models with greater efficacy than ESI-09^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 5-6 weeks old, 4T1 cell xenograft model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; every two days; 14 days
Result:

Significantly reduced tumor volume and tumor weight compared to DMSO control.
Significantly lowered tumor microvessel density (measured via CD31 IHC staining) and tumor cell proliferation index (measured via Ki67 IHC staining) compared to DMSO control.
Exhibited greater inhibitory effects on tumor volume, tumor weight, MVD, and proliferation index than ESI-09.
Showed no treatment-related organ toxicities via H&E staining of heart, liver, lung, brain, spleen, kidney, and intestine tissues.

Animal Model:

White leghorn (7-day-old embryo, CAM vascularization model)^[1]
Dosage:

25 μM, 50 μM, 100 μM
Administration:

topical application to CAM; single dose; 48-hour incubation
Result:

Significantly reduced CAM microvessel density at 100 μM compared to DMSO control.
Exhibited greater inhibitory effects on angiogenesis at 100 μM than ESI-09 at the same concentration.

Chemical Information

CAS No. 1801911-70-5
분자량 399.66
화학식 C₁₆H₁₃Cl₃N₄O₂
SMILES

N#CC(=NNC1=CC(Cl)=C(Cl)C(Cl)=C1)C(=O)C2=NOC(=C2)C(C)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li Z, et al. EPAC inhibitor suppresses angiogenesis and tumor growth of triple-negative breast cancer. Biochim Biophys Acta Mol Basis Dis. 2024;1870(4):167114. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NY0123

All Ras Isoforms

All Akt Isoforms

All ERK Isoforms

All VEGFR Isoforms