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Cat. No.: HY-182427

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ORF 17583

ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.

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CAS No.: 78441-46-0
화학식: C₁₃H₂₁N₅O₂S₂
분자량:343.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ORF 17583 Chemical Structure

CAS No.: 78441-46-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Bioz

Biological Activity

제품 설명

All Histamine Receptor Isoforms :

In Vitro

ORF 17583 (100-1000 nM; 30 min) exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing^[1].
ORF 17583 (1-10 μM; 60 min) significantly inhibits histamine-induced gastric acid secretion at a concentration of 10 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 78441-46-0
분자량 343.47
화학식 C₁₃H₂₁N₅O₂S₂
SMILES

O=S1N=C(C(NCCSCC2=CC=C(CN(C)C)O2)=N1)NC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Di Stilo A, et al. SAR studies on H2 antagonists containing alkylamino substituted 1,2, 5-thiadiazole 1-oxide moieties. Farmaco. 1998;53(8-9):536-540. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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ORF 17583

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ORF 17583 Related Classifications

HY-182427 Related Classifications