PCA-IN-1
PCA-IN-1 is a polyisoprenylated cysteinyl amide (PCA) inhibitor that acts on multiple KRAS mutant subtypes. PCA-IN-1 dissociates KRAS4B from its transport chaperones, prevents its localization to the plasma membrane, and blocks downstream oncogenic signaling pathways. PCA-IN-1 inhibits colony formation of KRAS-mutant lung cancer cells, induces sustained long-term growth inhibition, and suppresses cell migration. PCA-IN-1 is applicable to the research of KRAS-mutant lung cancer.
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- 화학식: C33H58N4O2S
- 분자량:574.90
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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KRAS(G12C) |
KRAS(G12A) |
PCA-IN-1 (PCAIs) (3 μM; 12 days) exerts broad anti-tumor activity by inhibiting colony formation in NCI-H23 KRASG12C and NCI-H23 KRASG12A cells[1].
NSL-YHJ-2-27 potently inhibits the viability of NCI-H23 KRASG12C (IC50 = 3.0 μM) and NCI-H23 KRASG12A (IC50 = 3.2 μM) cells, with consistent efficacy across different mutants[1].
PCA-IN-1 (26 d) exerts broad and sustained long-term growth inhibitory effects on NCI-H23 KRASG12C and NCI-H23 KRASG12A cells[1].
PCA-IN-1 (3 d) significantly inhibits the migration of NCI-H23 KRASG12C and NCI-H23 KRASG12A cells, whereas Sotorasib (HY-114277) only inhibits the migration of cells carrying the KRASG12C mutant[1].
PCA-IN-1 alters the transcriptome profile of KRAS-mutant NCI-H23 cells, with the changes enriched in signal transduction, cell adhesion and cancer-related pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H23 KRASG12C, NCI-H23 KRASG12A
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Concentration:3 μM
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Incubation Time:12 days
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Result:Inhibited colony formation comparably to Sotorasib in NCI-H23 KRASG12C cells.
Showed significantly greater effectiveness in NCI-H23 KRASG12A cells than Sotorasib.
Chemical Information
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분자량 574.90
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화학식 C33H58N4O2S
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CSCC(C(NC1CCCCCCC1)=O)NC(CN2CCN(CC2)C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCA-IN-1 Related Classifications
HY-183625 Related Classifications
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