Penicillin G
Based on 29 publication(s) in Google Scholar
Penicillin G is a potent penicillinantibiotic. Penicillin G can be used for bacterial infection. Penicillin G has potent activity against all Gram-positive bacteria and Gram-negative cocci.
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- CAS No.: 61-33-6
- 화학식: C16H18N2O4S
- 분자량:334.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) Penicillin G
More- Cancer Res. 2023 Apr 4;83(7):1048-1061. [Abstract]
- J Adv Res. 2026 Aug 1:S2090-1232(26)00605-3.
- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- Genes Dis. 2025 Apr 9;13(2):101625. [Abstract]
- Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
- J Control Release. 2024 Dec:376:1316-1328. [Abstract]
- J Neuroinflammation. 2025 Aug 26;22(1):207. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- Talanta. 2026 Jul 15;312(Pt A):130306.
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Int Immunopharmacol. 2026 Oct 1:186:117098.
- Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
- Int Immunopharmacol. 2024 Feb 15:128:111524. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- BMC Complement Med Ther. 2023 Jul 1;23(1):218. [Abstract]
- Front Physiol. 2020 Dec 23:11:605982. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Water. 2025 Jun 6.
- Oncol Lett. 2025 Jun 10;30(2):387. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
- Authorea. 2026 May 12.
- Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7419-7429. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
Customer Validation & Images
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Microbiological Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
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WB
All Antibiotic Isoforms
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Biological Activity
제품 설명
IC50 & Target
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β-lactam |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
89.4 μM
Compound: Penicillin G
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
| HepG2 | IC50 |
>10000 μM
Compound: PNC
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 24953953] |
| HepG2 | IC50 |
>10000 μM
Compound: PNC
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Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
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[PMID: 25593095] |
| Macrophage | CC50 |
228.9 μM
Compound: Penicillin G
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Cytotoxicity against human macrophages after 24 hrs by MTT assay
Cytotoxicity against human macrophages after 24 hrs by MTT assay
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[PMID: 24561667] |
| Macrophage | IC50 |
185.72 μM
Compound: Penicillin G
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Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay
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[PMID: 25306465] |
In Vitro
Penicillin G (16-128 μg/mL, 0-20 h) is used in combination with promethazine (32 μg/mL) to inhibit the growth and viability of E. coli[2].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61-33-6
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분자량 334.39
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화학식 C16H18N2O4S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O
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Synonyms
Benzylpenicillin
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (29)
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Journal Impact Factor
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Most Recent
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Cancer Res
HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. [Abstract]2023 Apr 4;83(7):1048-1061. PMID: 36745032 -
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Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
Genes Dis
Low expression of OXCT1 promote colorectal cancer liver metastasis by upregulating CDK8 and β-catenin via H3 acetylation. [Abstract]2025 Apr 9;13(2):101625. PMID: 41492470 -
Adv Sci (Weinh)
2025 Jul 17:e03098. PMID: 40673882
Penicillin G purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
Colony formation assays evaluated Staphylococcus aureus (ATCC 6538) after Penicillin G (Penicillin G potassium; 50-100 μM; 12 or 24 h). Penicillin G (50 and 100 μm) had good inhibition effects against S. aureus (ATCC6538) for 12 and 24 h.
Penicillin G purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
Bacterial colonies and viable bacterial burden in wound tissue were assessed on day 3 in a mouse model of MRSA (USA300)-infected wounds. Penicillin G (Penicillin G potassium; 100 μM; topical application to the wound; twice daily at 10 µL each time) significantly reduced the viable MRSA burden in the wound tissue.
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J Control Release
2024 Dec:376:1316-1328. PMID: 39490420 -
J Neuroinflammation
Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice. [Abstract]2025 Aug 26;22(1):207. PMID: 40859333 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
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Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
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Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2026 Feb 1:170:116080. PMID: 41429063 -
Int Immunopharmacol
Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. [Abstract]2024 Feb 15:128:111524. PMID: 38232537 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
BMC Complement Med Ther
Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis. [Abstract]2023 Jul 1;23(1):218. PMID: 37393274 -
Front Physiol
Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms. [Abstract]2020 Dec 23:11:605982. PMID: 33424630
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin had greater wet cecum weight/body weight and net cecum weight/body weight in C57BL/6.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin significantly increased the serum 5-HT concentration in C57BL/6.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) combined with streptomycin significantly increased HCN2 expression in the cecal epithelium of C57BL/6.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) led to significant reductions of acetic acid, butyrate, isobutyrate, and isovalerate levels but slight increases of propionate in the cecum, compared with the control group.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) had larger and heavier cecum compared with the control mice.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL; drinking water for 10 days) had significant up-regulation of HCN2 expression in the cecal mucosa.
Penicillin G purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Dec 23:11:605982. [Abstract]
Penicillin G sodium salt (2 mg/mL;drinking water for 10 days) significantly prolonged intestinal transit time and fecal water content.
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Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
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Oncol Lett
Propionate metabolism-related genes demonstrate the potential to serve as prognostic and immunotherapeutic markers in osteosarcoma. [Abstract]2025 Jun 10;30(2):387. PMID: 40535100 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329 -
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Eur Rev Med Pharmacol Sci
Novel long non-coding RNA LBX2-AS1 indicates poor prognosis and promotes cell proliferation and metastasis through Notch signaling in non-small cell lung cancer. [Abstract]2019 Sep;23(17):7419-7429. PMID: 31539129 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
순도&문서
References
[1]. Li D, et al. Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river. Water Res. 2008 Jan;42(1-2):307-17. [Content Brief]
[2]. Lehtinen J, et al. Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents. 2007 Jul;30(1):44-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penicillin G Related Classifications
HY-N7139 Related Classifications
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