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Cat. No.: HY-158721

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Penicinoline

Name: Penicinoline
Brand: MedChemExpress
SKU: HY-158721
Availability: PreOrder

(Synonyms: Marinamide)

Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells.

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CAS No.: 1214268-60-6
화학식: C₁₄H₁₀N₂O₃
분자량:254.24

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Penicinoline Chemical Structure

CAS No.: 1214268-60-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Classifications
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Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 20452770]
HEp-2	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 20452770]
HepG2	IC₅₀	6.5 μg/mL Compound: 1	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 20452770]
HepG2	IC₅₀	7 nM Compound: 68a	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30660827]
KB	IC₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 20452770]

Chemical Information

CAS No. 1214268-60-6
분자량 254.24
화학식 C₁₄H₁₀N₂O₃
SMILES

O=C(C1=C(C2=CC=CN2)NC3=C(C=CC=C3)C1=O)O
Synonyms

Marinamide
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Penicillium sp.
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shao CL, et al. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3284-6. [Content Brief]

[2]. Naveen B, et al. Total synthesis of penicinoline E, marinamide, methyl marinamide and their antimalarial activity[J]. ChemistrySelect, 2017, 2(11): 3256-3261.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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Penicinoline

(R)-(+)-Trityl glycidyl ether

Quassin

Violacein

MMP-9/MMP-13 Inhibitor I

Artemether-d3

Amodiaquine-d10

Piliformic acid

Quassin (Standard)

Xanthoquinodin A1

3-Oxobetulin acetate

6-Prenylindole

All Endogenous Metabolite Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Penicinoline

(R)-(+)-Trityl glycidyl ether

Quassin

Violacein

MMP-9/MMP-13 Inhibitor I

Artemether-d3

Amodiaquine-d10

Piliformic acid

Quassin (Standard)

Xanthoquinodin A1

3-Oxobetulin acetate

6-Prenylindole

All Endogenous Metabolite Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Penicinoline Related Classifications

HY-158721 Related Classifications

Bioz