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Cat. No.: HY-148525

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PF-4348235

(Synonyms: β2AR/M-receptor agonist-2)

β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC₅₀ value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a K_i value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD).

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CAS No.: 1017857-38-3
화학식: C₃₆H₄₉ClN₄O₇S
분자량:717.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PF-4348235 Chemical Structure

CAS No.: 1017857-38-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All mAChR Isoforms :

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	3.7 nM Compound: 15	Agonist activity at human beta-2 adrenoceptor expressed in CHO cells assessed as stimulation of intracellular cAMP production Agonist activity at human beta-2 adrenoceptor expressed in CHO cells assessed as stimulation of intracellular cAMP production	10.1039/C1MD00140J

In Vivo

β2AR/M-receptor agonist-2 dose-dependently inhibits methacholine-induced bronchoconstriction in dogs with an ID₅₀ value of 50 mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1017857-38-3
분자량 717.31
화학식 C₃₆H₄₉ClN₄O₇S
SMILES

O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CNCCCCCCCCCN(CC2)CCC2OC(NC3=C(C4=CC(Cl)=C(C=C4)O)C=CC=C3)=O
Synonyms

β2AR/M-receptor agonist-2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011.

Calculators

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Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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PF-4348235

All mAChR Isoforms

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PF-4348235 Related Classifications

HY-148525 Related Classifications