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Cat. No.: HY-124947

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PF-4522654

PF-4522654 is a potent, selective and brain-permeable 5-HT_2C receptor agonist with an EC₅₀ of 16 nM and a K_i of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT_2A and 5-HT_2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI).

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CAS No.: 1065109-28-5
화학식: C₁₆H₁₈F₂N₄
분자량:304.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PF-4522654 Chemical Structure

CAS No.: 1065109-28-5

사이즈

가격

재고

수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT_2B Receptor

5-HT_2C Receptor

16 nM (EC₅₀)

5-HT_2C Receptor

8 nM (Ki)

5-HT_2B Receptor

>10000 nM (EC₅₀)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 1065109-28-5
분자량 304.34
화학식 C₁₆H₁₈F₂N₄
SMILES

FC(C1=NC(CCNCC2)=C2C(NC)=N1)(C3=CC=CC=C3)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. R Ian Storer, et al. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem. 2014 Jun 26;57(12):5258-69. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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PF-4522654

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PF-4522654 Related Classifications

HY-124947 Related Classifications