PY109
Based on 1 Customer Validation
PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis.
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- Purity: 99.15%
- CAS No.: 2378039-23-5
- 화학식: C15H9F3N2O
- 분자량:290.24
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
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Biological Activity
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CYP1A1 |
IL-22 |
IL-17A |
Chemical Information
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CAS No. 2378039-23-5
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Appearance Solid
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분자량 290.24
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화학식 C15H9F3N2O
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Color Off-white to light yellow
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SMILES
O=C(C1=CNC2=C1C=CC=C2)C3=NC(C(F)(F)F)=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (344.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (252 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4454 mL | 17.2271 mL | 34.4542 mL | 86.1356 mL |
| 5 mM | 0.6891 mL | 3.4454 mL | 6.8908 mL | 17.2271 mL | |
| 10 mM | 0.3445 mL | 1.7227 mL | 3.4454 mL | 8.6136 mL | |
| 15 mM | 0.2297 mL | 1.1485 mL | 2.2969 mL | 5.7424 mL | |
| 20 mM | 0.1723 mL | 0.8614 mL | 1.7227 mL | 4.3068 mL | |
| 25 mM | 0.1378 mL | 0.6891 mL | 1.3782 mL | 3.4454 mL | |
| 30 mM | 0.1148 mL | 0.5742 mL | 1.1485 mL | 2.8712 mL | |
| 40 mM | 0.0861 mL | 0.4307 mL | 0.8614 mL | 2.1534 mL | |
| 50 mM | 0.0689 mL | 0.3445 mL | 0.6891 mL | 1.7227 mL | |
| 60 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4356 mL | |
| 80 mM | 0.0431 mL | 0.2153 mL | 0.4307 mL | 1.0767 mL | |
| 100 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8614 mL |
PY109 Related Classifications
HY-147128 Related Classifications
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