SC83288

SC83288 (72 h) potently inhibits wild-type P. falciparum 3D7 blood-stage growth with an IC₅₀ of 8 nM, while the PfATP6^F972Y mutant (E4) exhibits high resistance with an IC₅₀ of 5 μM^[1].
SC83288 (100 nM; 15 min) is transported via ATP-dependent mediation by PfATP6, particularly the PfATP6^F972Y mutant, with the mutant showing enhanced transport efficiency that is competed by Ca^2+[1].
SC83288 (50 nM; 0-60 min) is taken up ~100-fold by wild-type 3D7 and E4 mutant P. falciparum-infected erythrocytes via parasite-induced new permeation pathways, with no difference in uptake between the two lines^[1].
SC83288 (30 nM; 0-52 h) blocks DNA replication in wild-type P. falciparum Dd2 and 3D7 blood-stage parasites when added during early ring to trophozoite stages, but has no effect on the E4 (PfATP6^F972Y mutant) line^[1].
SC83288 (5-10 nM; 4.5 h) treatment of P. falciparum 3D7 trophozoites induces transcriptional upregulation of genes linked to epigenetic regulation, karyokinesis, and stress responses^[1].
SC83288 (40 nM; 12 h) disrupts methylation-related metabolism in P. falciparum 3D7 trophozoites, with no effect on the E4 (PfATP6^F972Y mutant) line^[1].
SC83288 (80 nM; 4 h) reduces global RNA m⁶A and DNA m⁵C methylation, and inhibits nuclear DNA methyltransferase activity in P. falciparum trophozoites, with the activity inhibition reversible by SAM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.