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Cat. No.: HY-181828

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SePP

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a K_i of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome.

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CAS No.: 3118902-53-4
화학식: C₁₇H₂₁NSe
분자량:318.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SePP Chemical Structure

CAS No.: 3118902-53-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

NMDA Receptor

28.7 nM (Ki)

All iGluR Isoforms :

All Dopamine Receptor Isoforms :

In Vitro

SePP (multiple concentrations; 2 h) potently binds to rat forebrain NMDARs with a K_i of 28.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Plasma Concentration
Mice^[1]	10 mg/kg	i.p.	387.5 ng/mL

In Vivo

SePP (10 mg/kg; i.p.) completely suppresses audiogenic seizures in juvenile Fmr1 knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

FVB.129P2-Pde6b+ Tyrc‑ch Fmr1tm1Cgr/J (Fmr1 knockout, 4 male and 4 female, postnatal day 23-25, audiogenic seizure induction)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; single dose
Result:

Abolished wild running and jumping (WRJ), tonic-clonic seizure (TCS), and respiratory arrest (RA) in all treated mice, with statistically significant differences compared to vehicle controls (P < 0.0001 for WRJ and TCS, P = 0.0013 for RA).
Exhibited normal behaviors including exploring, rearing, grooming, and interacting with cage-mates during testing.

Chemical Information

CAS No. 3118902-53-4
분자량 318.32
화학식 C₁₇H₂₁NSe
SMILES

C1(CC(N2CCCCC2)C3=CC=C[Se]3)=CC=CC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wallach J, et al. Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome. J Med Chem. 2026;69(4):4020-4036. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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SePP

All iGluR Isoforms

All Dopamine Receptor Isoforms