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Cat. No.: HY-168536

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SJ46411

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C).

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CAS No.: 3086104-39-1
화학식: C₁₇H₁₄N₂O₃S
분자량:326.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SJ46411 Chemical Structure

CAS No.: 3086104-39-1

사이즈

가격

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C)^[1].

IC₅₀ & Target

KLHDC2

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 3086104-39-1
분자량 326.37
화학식 C₁₇H₁₄N₂O₃S
SMILES

O=C(CNC(CC1=CSC(C2=CC=C3C=CC=CC3=C2)=N1)=O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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SJ46411

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SJ46411 Related Classifications

HY-168536 Related Classifications