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Cat. No.: HY-123773

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SR-16157

(Synonyms: NSC 732011; HLX-801)

SR-16157 (NSC 732011; HLX-801) is a dual-action steroid sulfatase (STS) inhibitor (IC₅₀ = 0.1 uM) and selective ERα modulator. SR-16157 exhibits STS inhibitory and anti-estrogenic effects in breast cancer cells. SR-16157 may be used in breast cancer research.

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CAS No.: 943344-76-1
화학식: C₂₇H₄₄N₂O₄S
분자량:492.71

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SR-16157 Chemical Structure

CAS No.: 943344-76-1

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수량

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	100 nM Compound: 15a; SR 16157	Inhibition of estrone sulfatase in human MCF7 cells using [3H]-estrone sulphate as substrate incubated for 30 mins by liquid scintillation counting method Inhibition of estrone sulfatase in human MCF7 cells using [3H]-estrone sulphate as substrate incubated for 30 mins by liquid scintillation counting method	[PMID: 26974384]

Chemical Information

CAS No. 943344-76-1
분자량 492.71
화학식 C₂₇H₄₄N₂O₄S
SMILES

O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](CCOCCN(CC)CC)CC[C@@]4([H])[C@]3([H])[C@H](C)CC2=C1)(N)=O
Synonyms

NSC 732011; HLX-801
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rasmussen LM, et al. A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer. Breast Cancer Res Treat. 2007 Dec;106(2):191-203. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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SR-16157

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SR-16157 Related Classifications

HY-123773 Related Classifications