SR10098
Based on 1 Customer Validation
SR10098 is a benzimidazole-based Nurr1 activator with an EC50 of 24 nM against full-length Nurr1. SR10098 does not directly bind to the ligand-binding domain of Nurr1, regulates transcription via a Nurr1-independent pathway, and exhibits no significant cytotoxicity. SR10098 can be used in studies of Nurr1-related diseases, such as Alzheimer's disease and Parkinson's disease.
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- Purity : ≥95.0%
- CAS No.: 850705-30-5
- 화학식: C14H9FN2O2
- 분자량:256.24
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
Nurr1/NR4A2 24 nM (EC50) |
In Vitro
SR10098 (compound 1) weakly upregulates Nurr1-mediated transcription in HEK293T, PC12 and SK-N-BE (2)-C cells; it activates general transcription via a Nurr1-independent mechanism[1].
SR10098 (400 μM) does not directly bind to the ligand-binding domain of Nurr1, as determined by protein NMR structural footprinting[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 850705-30-5
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Appearance Solid
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분자량 256.24
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화학식 C14H9FN2O2
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Color White to off-white
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SMILES
O=C(O)C1=CC=C2N=C(NC2=C1)C=3C=CC(F)=CC3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
순도&문서
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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