TEAD-IN-2
Based on 1 Customer Validation
TEAD-IN-2 is a novel, orally active inhibitor of transcriptional enhancer associate domain (TEAD) and modulates TEAD by ubiquitination and/or degradation by compounds. TEAD-IN-2 can be used for the research of a variety of diseases, disorders or conditions associated with TEAD.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.14%
- CAS No.: 2563849-97-6
- 화학식: C16H18BrF3N2O
- 분자량:391.23
-
보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-138565
K-975YAP1/TAZ-TEAD Inhibitor -
HY-134956
VT104YAP/TAZ Inhibitor -
HY-134955
VT103TEAD1 Palmitoylation Inhibitor -
HY-138489
TRULILat1/2 kinases Inhibitor -
HY-147208
MSC-4106YAP/TAZ-TEAD Inhibitor -
HY-147082
GA-017LATS1/2 Inhibitor -
HY-150042
TDI-011536Lats Kinase Inhibitor -
HY-147135
MYF-03-69TEAD Inhibitor -
HY-134957
VT107pan-TEAD Auto-Palmitoylation Inhibitor -
HY-125016
TT-10YAP-TEAD Activator -
HY-147322
YAP/TAZ inhibitor-2TEAD-YAP/TAZ Inhibitor -
HY-139603
MYF-01-37TEAD Inhibitor
All YAP Isoforms
More
Biological Activity
제품 설명
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H226 | IC50 |
<2 μM
Compound: 154; I-186
|
Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth by Cell Titer Glo assay
Antiproliferative activity against human NCI-H226 cells assessed as inhibition of cell growth by Cell Titer Glo assay
|
[PMID: 36063664] |
Chemical Information
-
CAS No. 2563849-97-6
-
Appearance Solid
-
분자량 391.23
-
화학식 C16H18BrF3N2O
-
Color White to off-white
-
SMILES
FC(C1=CC=C(CN2CCC(C3CC(Br)=NO3)CC2)C=C1)(F)F
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (255.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.39 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.39 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5560 mL | 12.7802 mL | 25.5604 mL | 63.9010 mL |
| 5 mM | 0.5112 mL | 2.5560 mL | 5.1121 mL | 12.7802 mL | |
| 10 mM | 0.2556 mL | 1.2780 mL | 2.5560 mL | 6.3901 mL | |
| 15 mM | 0.1704 mL | 0.8520 mL | 1.7040 mL | 4.2601 mL | |
| 20 mM | 0.1278 mL | 0.6390 mL | 1.2780 mL | 3.1951 mL | |
| 25 mM | 0.1022 mL | 0.5112 mL | 1.0224 mL | 2.5560 mL | |
| 30 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1300 mL | |
| 40 mM | 0.0639 mL | 0.3195 mL | 0.6390 mL | 1.5975 mL | |
| 50 mM | 0.0511 mL | 0.2556 mL | 0.5112 mL | 1.2780 mL | |
| 60 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 80 mM | 0.0320 mL | 0.1598 mL | 0.3195 mL | 0.7988 mL | |
| 100 mM | 0.0256 mL | 0.1278 mL | 0.2556 mL | 0.6390 mL |
TEAD-IN-2 Related Classifications
HY-147088 Related Classifications
Powered by Bioz