Cat. No.: HY-W112938

TMPyP tetrachloride

10 Cited Publications

고객리뷰

Based on 10 publication(s) in Google Scholar

TMPyP tetrachloride is a quadruplex-specific ligand. TMPyP tetrachloride inhibits the interaction between G-quadruplexes and IGF-1. TMPyP tetrachloride is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP tetrachloride is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP tetrachloride has antiviral activity against SARS-CoV-2.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.30%
CAS No.: 92739-63-4
화학식: C₄₄H₃₈Cl₄N₈
분자량:820.64

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

TMPyP tetrachloride Chemical Structure

CAS No.: 92739-63-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (10)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

TMPyP (50 µM, 96 h) tetrachloride inhibits telomerase activity in telomerase positive HOS cells^[2].
TMPyP (50 µM, 48 or 96 h) tetrachloride inhibits the growth of HOS cells^[2].
TMPyP (50 µM, 96 h) tetrachloride induces cell apoptosis in HOS, Saos-2, MG-63, and U2OS cell lines^[2].
TMPyP4 (100 µM, 24 or 48 h) tetrachloride increases cell cycle regulatory proteins and MAPKs in K562 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

HOS cells
Concentration:

50 µM
Incubation Time:

48 or 96 h
Result:

Time-dependently inhibited cell viability.

Western Blot Analysis^[4]

Cell Line:

K562 cells
Concentration:

100 µM
Incubation Time:

24 or 48 h
Result:

Increased the expression of p21^CIP1 protein and p57^KIP2 protein.

In Vivo

TMPyP (10 and 20 mg/kg, i.p., two times weekly) tetrachloride inhibits tumor growth in MX-1 tumor model^[5].
TMPyP (15 mg/kg or 30 mg/kg, i.n.) tetrachloride decreases the mean viral loads in SARS-CoV-2-infected hamster^[6].
TMPyP (30 mg/kg, i.n., hamsters) tetrachloride shows a C_max of 17.88 μg/mL at 1 h, and a half-life (T_1/2) of 6.36 h^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MX-1 mammary chemoadjuvant model^[5]
Dosage:

10 and 20 mg/kg
Administration:

Intraperitoneal injection (i.p.), twice weekly.
Result:

Inhibited tumor growth and prolonged mice survival.

Animal Model:

SARS-CoV-2-infected hamster^[6]
Dosage:

15 mg/kg or 30 mg/kg
Administration:

i.n., starting at 1 h prior to virus inoculation and continuing until 3 days post infection
Result:

Decreased the mean viral loads in the nasal wash, nasal turbinate and lung tissues.

Chemical Information

CAS No. 92739-63-4
Appearance Solid
분자량 820.64
화학식 C₄₄H₃₈Cl₄N₈
Color Dark purple to black
SMILES

C[N+](C=C1)=CC=C1/C(C2=CC=C(/C(C3=CC=[N+](C)C=C3)=C4N=C(/C(C5=CC=[N+](C)C=C5)=C6C=C/C(N/6)=C7\C8=CC=[N+](C)C=C8)C=C\4)N2)=C9C=CC7=N\9.[4Cl-]
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (10)

All Bio/Physico-chemical AssayFlow CytometryIn Vivo Efficacy Study

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Journal Impact Factor

Mol Cell

The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. [Abstract]

2024 Jun 6;84(11):2070-2086.e20. PMID: 38703770
Nat Commun

Telomeric repeat-containing RNA G-quadruplexes trigger ZBP1-mediated cell death. [Abstract]

2026 Feb 23;17(1):3076. PMID: 41730904
Nat Commun

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. [Abstract]

2024 Oct 4;15(1):8602. PMID: 39366945

TMPyP tetrachloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 4;15(1):8602. [Abstract]

Luciferase transcriptional activation assays in HeLa cells of promoter regions of Dhx36, Kcne1, Bcl2l11, Ntn1, Ppargc1a (Pgc1a), Fhl2, and Nr4a1 cloned in pGL4.25 luciferase expressing vector. The luciferase activity, measured in Relative light units (R.L.U.) of the different constructs, are shown in the presence or absence of the G4 stabilization drug TMPyP4 tosylate (20 μM; 24 h).
Nucleic Acids Res

RNA G-quadruplexes promote codon repeat-associated ribosomal frameshifting in human genes. [Abstract]

2026 Jan 14;54(2):gkaf1481. PMID: 41543171

TMPyP tetrachloride purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1481. [Abstract]

Treatment with TMPyP4 tosylate (2 μM; 26 h) resulted in a 14.18% reduction in the HDAC1 frameshifting ratio in HEK293T cells, whereas the mut1 rG4 mutant exhibited only a minimal reduction (1.88%) compared with the control group.

TMPyP tetrachloride purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1481. [Abstract]

The G4-destabilizing porphyrin TMPyP4 tosylate (1-100 μM) induced a concentration-dependent shift in the spectral peak, indicating a transition of the higher order HDAC1 RNA structure to a linear form. Moreover, the high concentration (100 μM) of TMPyP4 disrupted the standard CD spectrum of the G4 structure.
Cell Death Dis

Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity. [Abstract]

2024 Nov 11;15(11):816. PMID: 39528472

TMPyP tetrachloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Nov 11;15(11):816. [Abstract]

TMPyP4 tosylate (4-8 μM; 48 h) induced a significant increase in apoptosis in CRC cell lines.

TMPyP tetrachloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Nov 11;15(11):816. [Abstract]

TMPyP4 tosylate (30 mg/kg; i.p.; three times a week) markedly decreased tumor weights and volumes of BALB/c nude mice bearing SW620 colorectal tumors.
Int J Biol Macromol

I-motif formation in the promoter region of the B-MYB proto-oncogene. [Abstract]

2025 Jan 9:139582. PMID: 39798757
Anal Chem

Single-Molecule Detection on Intrastrand Interactions among G4 Clusters. [Abstract]

2025 Jun 10;97(22):11617-11626. PMID: 40408126
Microbiol Spectr

Characterization of G-Quadruplexes in Enterovirus A71 Genome and Their Interaction with G-Quadruplex Ligands. [Abstract]

2022 Apr 21;e0046022. PMID: 35446122
Biochemistry

G-Quadruplex-Mediated Transcriptional Regulation of SYT7: Implications for Tumor Progression and Therapeutic Strategies. [Abstract]

2024 Oct 15;63(20):2609-2620. PMID: 39320967
Virology

The UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication. [Abstract]

2024 Dec 24:603:110378. PMID: 39731905

용액&용해도

In Vitro:

H₂O : 50 mg/mL (60.93 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2186 mL

6.0928 mL

12.1856 mL

5 mM

0.2437 mL

1.2186 mL

2.4371 mL

10 mM

0.1219 mL

0.6093 mL

1.2186 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen H, et al. Insuline-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38. [Content Brief]

[2]. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11. [Content Brief]

[3]. Fujiwara N, et al. a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase Inhibitor. PLoS One. 2015 Sep 24;10(9):e0139167. [Content Brief]

[4]. Mikami-Terao Y, et al. Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells. Cancer Lett. 2008 Mar 18;261(2):226-34. [Content Brief]

[5]. Grand CL, et al. The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. Mol Cancer Ther. 2002 Jun;1(8):565-73. Erratum in: Mol Cancer Ther.2003 Feb;2(2):208. [Content Brief]

[6]. Qin G, et al. RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models. Cell Discov. 2022 Sep 6;8(1):86. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.2186 mL	6.0928 mL	12.1856 mL	30.4640 mL
	5 mM	0.2437 mL	1.2186 mL	2.4371 mL	6.0928 mL
	10 mM	0.1219 mL	0.6093 mL	1.2186 mL	3.0464 mL
	15 mM	0.0812 mL	0.4062 mL	0.8124 mL	2.0309 mL
	20 mM	0.0609 mL	0.3046 mL	0.6093 mL	1.5232 mL
	25 mM	0.0487 mL	0.2437 mL	0.4874 mL	1.2186 mL
	30 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0155 mL
	40 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.7616 mL
	50 mM	0.0244 mL	0.1219 mL	0.2437 mL	0.6093 mL
	60 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.5077 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

TMPyP tetrachloride

10 Cited Publications

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TMPyP tetrachloride

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Neuronal Signaling Compound Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) TMPyP tetrachloride

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Publications (10)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

TMPyP tetrachloride

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Neuronal Signaling Compound Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) TMPyP tetrachloride

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Publications (10)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

TMPyP tetrachloride Related Classifications

HY-W112938 Related Classifications