TSI-01
Based on 1 Customer Validation
TSI-01 is a selective LPCAT2 inhibitor, with IC50 values of 0.47 μM and 3.02 μM against LPCAT2 and LPCAT1, respectively. TSI-01 competitively inhibits acetyl-CoA (acetyl-CoA) targeting the lysophosphatidic acid acetyltransferase activity of LPCAT2, and suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages. TSI-01 inhibits the proliferation of endometrial cancer cells and promotes endometrial cancer cell apoptosis (apoptosis). TSI-01 can be used for the research of endometrial cancer and PAF-related inflammatory diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.52%
- CAS No.: 704878-75-1
- 화학식: C14H11Cl2NO4
- 분자량:328.15
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
TSI-01 (0-40 μM) potently inhibits the viability of human endometrial cancer Ishikawa cells with an IC50 of 7.56 μM and HEC-1A cells with an IC50 of 9.31 μM[1].
TSI-01 (0-10 μM) concentration-dependently promotes apoptosis in human endometrial cancer Ishikawa and HEC-1A cells, with 10 μM inducing the highest levels of early and late apoptosis[1].
TSI-01 (0.1-100 μM; 1 h) dose-dependently inhibits A23187-induced PAF production in RAW-mLPCAT2 cells with an IC50 of 38.8 μM, without reducing cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 704878-75-1
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Appearance Solid
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분자량 328.15
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화학식 C14H11Cl2NO4
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Color White to off-white
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SMILES
O=C(C1=CC=C(N2C(C(Cl)=C(C2=O)Cl)=O)C=C1)OC(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (380.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhao T, et al. Overexpression of LPCAT1 enhances endometrial cancer stemness and metastasis by changing lipid components and activating the TGF/β-Smad2/3 signaling pathway. Acta biochimica et biophysica Sinica. 2022 Jun 25;54(7):904-916. [Content Brief]
[2]. Tarui M, et al. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. Journal of lipid research. 2014 Jul;55(7):1386-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0474 mL | 15.2369 mL | 30.4739 mL | 76.1847 mL |
| 5 mM | 0.6095 mL | 3.0474 mL | 6.0948 mL | 15.2369 mL | |
| 10 mM | 0.3047 mL | 1.5237 mL | 3.0474 mL | 7.6185 mL | |
| 15 mM | 0.2032 mL | 1.0158 mL | 2.0316 mL | 5.0790 mL | |
| 20 mM | 0.1524 mL | 0.7618 mL | 1.5237 mL | 3.8092 mL | |
| 25 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0474 mL | |
| 30 mM | 0.1016 mL | 0.5079 mL | 1.0158 mL | 2.5395 mL | |
| 40 mM | 0.0762 mL | 0.3809 mL | 0.7618 mL | 1.9046 mL | |
| 50 mM | 0.0609 mL | 0.3047 mL | 0.6095 mL | 1.5237 mL | |
| 60 mM | 0.0508 mL | 0.2539 mL | 0.5079 mL | 1.2697 mL | |
| 80 mM | 0.0381 mL | 0.1905 mL | 0.3809 mL | 0.9523 mL | |
| 100 mM | 0.0305 mL | 0.1524 mL | 0.3047 mL | 0.7618 mL |
TSI-01 Related Classifications
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