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Cat. No.: HY-185893

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UNC11676A

UNC11676A is an MDA5 ATPase inhibitor with IC₅₀ values of 6 μM, 115 μM and 108 μM against MDA5, LGP2 and DDX1, respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3126213-85-9
화학식: C₂₃H₁₇F₃N₄O₄S₂
분자량:534.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

UNC11676A Chemical Structure

CAS No.: 3126213-85-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Helicase

All DNA/RNA Synthesis Isoforms :

In Vitro

UNC11676A potently and selectively inhibits truncated human MDA5ΔCARD ATPase activity (IC₅₀ = 6 μM), with 18-fold lower potency against full-length human LGP2 (IC₅₀ = 115 μM) and full-length human DDX1 (IC₅₀ = 108 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3126213-85-9
분자량 534.53
화학식 C₂₃H₁₇F₃N₄O₄S₂
SMILES

O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=C(C(F)(F)F)C=CC=C4)=O)S3)=CS2)C=C1OC)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5. European journal of medicinal chemistry. 2026 May 05;309:118724. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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수량:
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UNC11676A

All DNA/RNA Synthesis Isoforms