UNC8899
UNC8899 is a STING PROTAC degrader with a DC50 of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).
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- CAS No.: 3094059-37-4
- 화학식: C71H91N17O13S
- 분자량:1422.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
VHL |
In Vitro
UNC8899 (0-31.6 μM；24 h) degrades STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caki-1
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Concentration:0.01, 0.0316, 0.1, 0.316, 1, 3.16, 10, 31.6 μM
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Incubation Time:24 h
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Result:Degraded STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%.
Chemical Information
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CAS No. 3094059-37-4
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분자량 1422.65
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화학식 C71H91N17O13S
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SMILES
O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC8899 Related Classifications
HY-158046 Related Classifications
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