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Cat. No.: HY-150802

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VH101

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030).

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CAS No.: 2135318-53-3
화학식: C₂₆H₃₃FN₄O₄S
분자량:516.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VH101 Chemical Structure

CAS No.: 2135318-53-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030)^[1].

IC₅₀ & Target^[1]

VHL

All Ligands for E3 Ligase Isoforms :

In Vitro

VH101 (100 μM; 4.5 h) pretreatment of LRRK2^G2019S MEFs blocks XL01126-induced LRRK2 degradation, confirming VHL-dependent activity of the PROTAC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2135318-53-3
분자량 516.63
화학식 C₂₆H₃₃FN₄O₄S
SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liu X, et al. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society. 2022 Sep 21;144(37):16930-16952. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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VH101

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VH101 Related Classifications

HY-150802 Related Classifications