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Cat. No.: HY-P990691

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Biologically Validated

Vilamakitug

Name: Vilamakitug
Brand: MedChemExpress
SKU: HY-P990691
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: XB-2001)

고객리뷰

Based on 1 Customer Validation

Vilamakitug (XB-2001) is an anti-IL-1α monoclonal antibody that blocks IL-1α signaling. Vilamakitug binds to and neutralizes IL-1α. Vilamakitug can be used for research on metastatic colorectal cancer and melanoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 95.45%
CAS No.: 2458202-06-5
분자량:145.971 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Vilamakitug Chemical Structure

CAS No.: 2458202-06-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- 신청
- Verified Bioactivity
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]^[2]

IL-1α

All Interleukin Related Isoforms :

In Vivo

Anti-cancerCytokines & ChemokinesImmune Tolerance & ImmunosuppressionLocal Vascular Regulation

Anti-cancer

Cytokines & Chemokines

Immune Tolerance & Immunosuppression

Local Vascular Regulation

Vilamakitug (0.1-2.0 mg; i.p.; every 3 days; five doses) reduces pulmonary melanoma nodule burden, lung tumor area, and melanoma-associated biomarker expression in B16-F10 pulmonary metastasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

3552 [NCBI]

Accession

P01583

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG4-kappa

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-1 alpha Protein, Human (HY-P7027) can bind Vilamakitug. The EC₅₀ for this effect is 19.95 ng/mL.

Chemical Information

CAS No. 2458202-06-5
Appearance Liquid
분자량 145.971 kDa
Color Colorless to light yellow
Synonyms

XB-2001
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Mei HR, et al. The therapeutic potential of targeting IL-1α signaling pathways in a mouse model of pulmonary melanoma. Sci Rep. 2026;16(1):13452.

[2]. Thibaudin M, et al. Safety and efficacy of trifluridine/tipiracil +/- bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial. Signal transduction and targeted therapy. 2025 Jan 17;10(1):22.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- 신청
- Biological Activity
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Vilamakitug

All Interleukin Related Isoforms