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Cat. No.: HY-125577

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VRT-18858

(Synonyms: RU-36384)

VRT-18858 (RU-36384), the active metabolite of Pralnacasan (HY-19676), is a potent interleukin-1β converting enzyme (ICE) inhibitor (K_i = 1.4 nM). VRT-18858 inhibits LPS (HY-D1056)-induced IL-1β release (IC₅₀ = 0.42 µM) and S. aureus Cowan-induced IL-1β and IL-18 release (IC₅₀=1.3 and 2.1 µM, respectively) in human peripheral blood mononuclear cells. VRT-18858 can be used for osteoarthritis research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 192756-07-3
화학식: C₂₄H₂₅N₅O₇
분자량:495.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

VRT-18858 Chemical Structure

CAS No.: 192756-07-3

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

IL-1β

IL-18

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	0.38 μM Compound: 2a	Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA	[PMID: 20656488]
PBMC	IC₅₀	0.85 μM Compound: VRT-18858	Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin) Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin)	[PMID: 34823899]

Chemical Information

CAS No. 192756-07-3
분자량 495.48
화학식 C₂₄H₂₅N₅O₇
SMILES

O=C([C@@H](NC(C1=NC=CC2=C1C=CC=C2)=O)CC3)N([C@H](C(N[C@H](C=O)CC(O)=O)=O)CCC4)N4C3=O
Synonyms

RU-36384
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rudolphi K, et al. Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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VRT-18858

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VRT-18858 Related Classifications

HY-125577 Related Classifications