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Cat. No.: HY-N15384

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Wrightiadione

Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC₅₀ values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways.

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CAS No.: 148180-61-4
화학식: C₁₆H₈O₃
분자량:248.24

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Wrightiadione Chemical Structure

CAS No.: 148180-61-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

TrkA

55.8 μM (IC₅₀)

PLK3

9 μM (IC₅₀)

All Trk Receptor Isoforms :

All Polo-like Kinase (PLK) Isoforms :

In Vitro

Wrightiadione (compound 1) at 10 μM selectively inhibits TrkA and PLK3 against a kinome panel consisting of 97 cancer-related kinases in a high-throughput binding assay^[1].
Wrightiadione inhibits the activity of purified TrkA kinase in radiokinase assays, with an IC₅₀ value of 55.8 μM^[1].
Wrightiadione inhibits the kinase activity of purified PLK3 in radiometric kinase assays, with an IC₅₀ of 9.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148180-61-4
분자량 248.24
화학식 C₁₆H₈O₃
SMILES

O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
Structure Classification
- Flavonoids
- Isoflavones
- Flavonoids
- Other Flavonoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jeong Y, et al. Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors. Bioorganic & medicinal chemistry letters. 2015 Nov 15;25(22):5186-9.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Wrightiadione

All Trk Receptor Isoforms

All Polo-like Kinase (PLK) Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Wrightiadione Related Classifications

HY-N15384 Related Classifications

Bioz

Keywords

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