country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-176555

Copy Link Print Information

Z169667518

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 941127-19-1
화학식: C₂₃H₁₈N₄O
분자량:366.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Z169667518 Chemical Structure

CAS No.: 941127-19-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Z169667518 is an IL-6 inhibitor. Z169667518 inhibits IL-6-induced STAT3 reporter gene signaling^[1].

IC₅₀ & Target

^[1]

IL-6

STAT3

All Interleukin Related Isoforms :

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC50	2.7 μM	Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay. Inhibition of IL6-induced STAT3 luciferase reporter activity in HEK293T cells assessed after 5 hrs exposure by dual-luciferase reporter assay.	40733185

In Vitro

Z169667518 (10 µM; 5 h) inhibits IL6-induced STAT3 reporter activity in HEK293T cells, producing ~84% inhibition at 10 µM and an IC₅₀ of 2.7 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 941127-19-1
분자량 366.42
화학식 C₂₃H₁₈N₄O
SMILES

O=C(C1=CC=C(C=C1)C#CC2=CC=CC=C2)NCCC3=NN=C4C=CC=CN43
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Joshi A, et al. Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6. Molecules. 2025 Jul 10;30(14):2919. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Z169667518

All Interleukin Related Isoforms

All STAT Isoforms