L-652343
L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB4 in isolated human polymorphonuclear leukocytes treated with Calcimycin (HY-N6687) (IC50: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases.
For research use only. We do not sell to patients.
- CAS No.: 107008-29-7
- Formula: C22H14F3NO2S2
- Molecular Weight:445.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Leukotriene Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
LTB4 |
Chemical Information
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CAS No. 107008-29-7
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Molecular Weight 445.48
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Formula C22H14F3NO2S2
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SMILES
OC1=C(C(N/C=C(C2=CC=CC=C2)/C3=CC=CS3)=O)SC4=C1C=C(C(F)(F)F)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-652343 Related Classifications
HY-105933 Related Classifications
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