Isotope-Labeled Lipids

Dodecanedioic acid-d₄ is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.

Succinic acid-¹³C₂ is the ¹³C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].

3-Epi-25-hydroxyvitamin D3-¹³C₅ is the ¹³C labeled 3-Epi-25-hydroxyvitamin D3.

3-Epi-25-Hydroxyvitamin D3-d₃ is the deuterium labeled 3-Epi-25-Hydroxyvitamin D3.

Oleoyl coenzyme A-¹³C₁₈ (lithium) is the ¹³C labeled Oleoyl Coenzyme A lithium. Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite.

Cyclosporin A-d₃ (Cyclosporine A-d₃) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.

1β-Hydroxydeoxycholic Acid-d₅ is the deuterium labeled 1β-Hydroxydeoxycholic Acid.

DSPC-d₇₄ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₄) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.

17:0-17:1-17:0 TG-d₅ is deuterium labeled 17:0-17:1-17:0 TG.

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphatidylethanolamine-d₇ is deuterium labeled 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphatidylethanolamine.

22:0 Lyso PC-¹³C₆ is a ¹³C-labeled and deuterium labeled 22:0 Lyso PC.

C16-Ceramide-¹³C₁₆ is a ¹³C-labeled C16-Ceramide (HY-100354).

Tristearin-d₉ is the deuterium labeled Tristearin (HY-127035). Tristearin is a triglyceride derived from three units of stearic acid.

DL-Valine-d₂ is the deuterium labeled DL-Valine.

DL-Valine-d-1 is the deuterium labeled DL-Valine.

DL-Valine-d is the deuterium labeled DL-Valine.

Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[.

ω-3 Arachidonic Acid-d₈ is the deuterium labeled ω-3 Arachidonic Acid.

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.