1β-Hydroxydeoxycholic acid-d5
1β-Hydroxydeoxycholic acid-d5 (1β-OH-DCA-d5) is the deuterated-labeled 1β-Hydroxydeoxycholic acid (HY-113482). 1β-Hydroxydeoxycholic acid (1β-OH-DCA) is an endogenous bile acid metabolite formed from deoxycholic acid via CYP3A-mediated 1β-hydroxylation. 1β-Hydroxydeoxycholic acid undergoes rapid metabolism in human hepatocytes, primarily through glycine conjugation to form G-1β-OH-DCA, with minor taurine conjugation and sulfation. The urinary ratio of 1β-Hydroxydeoxycholic acid to deoxycholic acid can be used as an endogenous biomarker for assessing CYP3A activity. 1β-Hydroxydeoxycholic acid can be used in metabolism-related research.
For research use only. We do not sell to patients.
- Formula: C24H35D5O5
- Molecular Weight:413.60
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
CYP3A |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 80434-32-8
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Appearance Solid
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Molecular Weight 413.60
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Formula C24H35D5O5
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])[C@H]2O)([2H])O)([H])[C@@]4([H])[C@]([C@H](C3)O)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C
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Synonyms
1β-OH-DCA-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1β-Hydroxydeoxycholic acid-d5 Related Classifications
HY-113482S Related Classifications
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Keywords
- 1β-Hydroxydeoxycholic acid-d5
- 1β-OH-DCA-d5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Drug Intermediate
- Cytochrome P450
- Drug Iintermediate
- CYPs
- 1β-hydroxylation
- CYP3A
- CYP3A4
- CYP3A5
- CYP3A7
- biomarker
- endogenous bile acid metabolite
- glycine conjugation
- human hepatocytes
- human liver microsomes
- Inhibitor
- inhibitor
- inhibit