1. GPCR/G Protein
  2. Ras
  3. MLS000532223

MLS000532223 

Cat. No.: HY-117149 Purity: 99.47%
Handling Instructions

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity .

For research use only. We do not sell to patients.

MLS000532223 Chemical Structure

MLS000532223 Chemical Structure

CAS No. : 16616-39-0

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity [1].

IC50 & Target

EC50: 16-120 μM (Rho family GTPases)[1]

In Vitro

MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].
MLS000532223 modulates Rho-family GTP-binding kinetics[1].
MLS000532223 is active in cell–based assays and inhibits EGF-stimulated Rac 1 activation[1].
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].
MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].

Molecular Weight

251.24

Formula

C₁₅H₉NO₃

CAS No.

16616-39-0

SMILES

O=C(C1=CC=CC([N+]([O-])=O)=C1)C#CC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (199.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9803 mL 19.9013 mL 39.8026 mL
5 mM 0.7961 mL 3.9803 mL 7.9605 mL
10 mM 0.3980 mL 1.9901 mL 3.9803 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MLS000532223MLS 000532223MLS-000532223RasGTPasesRabRho GTPasesactincytoskeletonInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
MLS000532223
Cat. No.:
HY-117149
Quantity:
MCE Japan Authorized Agent: