MLS000532223
Based on 1 publication(s) in Google Scholar
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 16616-39-0
- Formula: C15H9NO3
- Molecular Weight:251.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MLS000532223
More
Biological Activity
EC50: 16-120 μM (Rho family GTPases)[1]
MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].
MLS000532223 modulates Rho-family GTP-binding kinetics[1].
MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation[1].
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].
MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16616-39-0
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Appearance Solid
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Molecular Weight 251.24
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Formula C15H9NO3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC([N+]([O-])=O)=C1)C#CC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Genomics Proteomics
Integrated Proteomics Reveal ALDH1A1 as an Oncogenic Driver and Regulatory Hub in Hepatocellular Carcinoma. [Abstract]2026 May-Jun;23(3):407-429. PMID: 42055623
Solvent & Solubility
DMSO : 50 mg/mL (199.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9803 mL | 19.9013 mL | 39.8026 mL | 99.5064 mL |
| 5 mM | 0.7961 mL | 3.9803 mL | 7.9605 mL | 19.9013 mL | |
| 10 mM | 0.3980 mL | 1.9901 mL | 3.9803 mL | 9.9506 mL | |
| 15 mM | 0.2654 mL | 1.3268 mL | 2.6535 mL | 6.6338 mL | |
| 20 mM | 0.1990 mL | 0.9951 mL | 1.9901 mL | 4.9753 mL | |
| 25 mM | 0.1592 mL | 0.7961 mL | 1.5921 mL | 3.9803 mL | |
| 30 mM | 0.1327 mL | 0.6634 mL | 1.3268 mL | 3.3169 mL | |
| 40 mM | 0.0995 mL | 0.4975 mL | 0.9951 mL | 2.4877 mL | |
| 50 mM | 0.0796 mL | 0.3980 mL | 0.7961 mL | 1.9901 mL | |
| 60 mM | 0.0663 mL | 0.3317 mL | 0.6634 mL | 1.6584 mL | |
| 80 mM | 0.0498 mL | 0.2488 mL | 0.4975 mL | 1.2438 mL | |
| 100 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9951 mL |
MLS000532223 Related Classifications
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