Multi-target kinase-IN-11
Multi-target kinase-IN-11 (compound 2a) is a potent multi-target inhibitor of Cholinesterase and Carbonic Anhydrase. Multi-target kinase-IN-11 inhibits AChE, BChE, hCA I, and hCA II with IC50 values of 2.78, 4.88, 0.94, and 4.15 μM, respectively. Multi-target kinase-IN-11 inhibits these enzymes through hydrogen bonding and electrostatic interactions with active site residues. Multi-target kinase-IN-11 can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C50H28N10O6Si
- Molecular Weight:892.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hCA I 0.94 μM (IC50) |
hCA II 4.15 μM (IC50) |
AChE 2.78 μM (IC50) |
BChE 4.88 μM (IC50) |
In Vitro
Multi-target kinase-IN-11 (compound 2a) (3-10 min) effectively inhibits hCA I (IC50 = 0.94 μM), hCA II (IC50 = 4.15 μM), AChE (IC50 = 2.78 μM), and BChE (IC50 = 4.88 μM) in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 892.91
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Formula C50H28N10O6Si
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SMILES
O=C(N1CO[Si]234(OCN5C(C6=CC=CC=C6C5=O)=O)[N]7=C8N=C9N2C(C%10=C9C=CC=C%10)=NC%11=[N]3C(C%12=C%11C=CC=C%12)=NC%13=C%14C=CC=CC%14=C(N=C7C%15=C8C=CC=C%15)N%134)C%16=CC=CC=C%16C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-target kinase-IN-11 Related Classifications
HY-189488 Related Classifications
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Keywords
- Multi-target kinase-IN-11
- Cholinesterase (ChE)
- Carbonic Anhydrase
- butyrylcholinesterase
- human carbonic anhydrase II
- hydrogen bonding
- Alzheimer's disease
- electrostatic interactions
- acetylcholinesterase
- human acetylcholinesterase
- human butyrylcholinesterase
- human carbonic anhydrase I
- carbonic anhydrase
- Inhibitor
- inhibitor
- inhibit