Flucopride
Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h)5-HT4R). Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4R (EC50: 23.0 nM). Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay).
For research use only. We do not sell to patients.
- CAS No.: 1639925-34-0
- Formula: C22H33FN2O2
- Molecular Weight:376.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
AChE 24 nM (IC50) |
huamn 5-HT4(c) Receptor 9.6 nM (Ki) |
Chemical Information
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CAS No. 1639925-34-0
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Molecular Weight 376.51
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Formula C22H33FN2O2
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SMILES
O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC3CCCCC3)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Flucopride Related Classifications
HY-168241 Related Classifications
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