2. Apoptosis
  3. Bcl-2 Family
  4. NPB

NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM.

For research use only. We do not sell to patients.

NPB Chemical Structure

NPB Chemical Structure

CAS No. : 2247491-97-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 323 In-stock
Solution
10 mM * 1 mL in DMSO USD 323 In-stock
Solid
5 mg USD 280 In-stock
10 mg USD 450 In-stock
25 mg USD 910 In-stock
50 mg USD 1450 In-stock
100 mg USD 2280 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1].

IC50 & Target

IC50: 0.41 μM (BAD at Ser99)[1]
Clinical Trial
Molecular Weight

524.48

Formula

C29H31Cl2N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C(N2CCN(C3=C(Cl)C(Cl)=CC=C3)CC2)C4=CC=CC(C(NC5CCCC5)=O)=C4)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9067 mL 9.5333 mL 19.0665 mL
5 mM 0.3813 mL 1.9067 mL 3.8133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9067 mL 9.5333 mL 19.0665 mL 47.6663 mL
5 mM 0.3813 mL 1.9067 mL 3.8133 mL 9.5333 mL
10 mM 0.1907 mL 0.9533 mL 1.9067 mL 4.7666 mL
15 mM 0.1271 mL 0.6356 mL 1.2711 mL 3.1778 mL
20 mM 0.0953 mL 0.4767 mL 0.9533 mL 2.3833 mL
25 mM 0.0763 mL 0.3813 mL 0.7627 mL 1.9067 mL
30 mM 0.0636 mL 0.3178 mL 0.6356 mL 1.5889 mL
40 mM 0.0477 mL 0.2383 mL 0.4767 mL 1.1917 mL
50 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.9533 mL
60 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7944 mL
80 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
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NPB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPB2247491-97-8Bcl-2 FamilyInhibitorinhibitorinhibit

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