2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. ONT-093

ONT-093  (Synonyms: OC 144-093; OC 144093)

Cat. No.: HY-15134 Purity: 99.21%
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ONT-093 is a potent inhibitor of P-glycoprotein pump. ONT-093 has the potential for the research cancer diseases.

For research use only. We do not sell to patients.

ONT-093 Chemical Structure

ONT-093 Chemical Structure

CAS No. : 216227-54-2

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1 mg USD 218 In-stock
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Based on 1 publication(s) in Google Scholar

ONT-093 Related Antibodies

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Description

ONT-093 is a potent inhibitor of P-glycoprotein pump. ONT-093 has the potential for the research cancer diseases[1].

Molecular Weight

494.67

Formula

C32H38N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)NC1=CC=C(C2=C(C3=CC=C(NC(C)C)C=C3)N=C(C4=CC=C(/C=C/COCC)C=C4)N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (252.69 mM; Need ultrasonic)

DMSO : 100 mg/mL (202.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0215 mL 10.1077 mL 20.2155 mL
5 mM 0.4043 mL 2.0215 mL 4.0431 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.0215 mL 10.1077 mL 20.2155 mL 50.5387 mL
5 mM 0.4043 mL 2.0215 mL 4.0431 mL 10.1077 mL
10 mM 0.2022 mL 1.0108 mL 2.0215 mL 5.0539 mL
15 mM 0.1348 mL 0.6738 mL 1.3477 mL 3.3692 mL
20 mM 0.1011 mL 0.5054 mL 1.0108 mL 2.5269 mL
25 mM 0.0809 mL 0.4043 mL 0.8086 mL 2.0215 mL
30 mM 0.0674 mL 0.3369 mL 0.6738 mL 1.6846 mL
40 mM 0.0505 mL 0.2527 mL 0.5054 mL 1.2635 mL
50 mM 0.0404 mL 0.2022 mL 0.4043 mL 1.0108 mL
60 mM 0.0337 mL 0.1685 mL 0.3369 mL 0.8423 mL
80 mM 0.0253 mL 0.1263 mL 0.2527 mL 0.6317 mL
100 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5054 mL
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ONT-093 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONT-093216227-54-2OC 144-093 OC 144093ONT093ONT 093OC144093OC 144093OC-144093P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243P-glycoprotein pumpcancerInhibitorinhibitorinhibit

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