Simaroubaceae Extract

Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects.

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1.

4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline.

Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia.

Bruceantarin is a potent antineoplastic agent. Bruceantarin can be used for leukemia and breast cancer research.

10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent.

1-Hydroxycanthin-6-one is an alkaloid that can be found in Ailanthus giraldii.

Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma.

Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.

Yadanzioside M is a natural compound with anti-cancer activity.

Yadanzioside L is a quassinoid and shows anti-tobacco mosaic virus (TMV) activity (IC₅₀=4.86 μM).

Yadanzioside C is a quassinoid glucoside found in seeds of Brucea amarissima.

Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells.

Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum.

Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor.

(E)-Cinnamamide (Standard) is the analytical standard of (E)-Cinnamamide (HY-W067479). This product is intended for research and analytical applications. (E)-Cinnamamide is a non-lethal chemical repellent. (E)-Cinnamamide exists as a trans-cinnamic acid amide metabolite in the culture broth of an unidentified Streptomyces No. 902. (E)-Cinnamamide is used in studies of conditioned taste aversion and repellent activity.

Bruceoside B is a PI3K/Akt/NF-κB inhibitor. Bruceoside B reduces LPS (HY-D1056)-induced nitric oxide release and the secretion of TNF-α, IL-6 and IL-1β, and decreases the activation level of apoptosis. Bruceoside B inhibits the replication, coat protein accumulation and local lesion formation of tobacco mosaic virus (TMV), and enhances the anti-infection ability of plants. Bruceoside B can be used in studies related to acute lung injury and tobacco mosaic virus infection.

Sapelin B is a naturally occurring tirucallane-type triterpenoid that exhibits in vivo antitumor activity in a mouse model of P-388 lymphocytic leukemia. Sapelin B can be used in leukemia-related research.

Ocotillone Ⅰ (20R-Ocotillone) is a Sesquiterpenoids product that can be isolated from the herbs of Rosa multiflora Thunb..

Glaucarubin is a bitter lactone found in Simaruba glauca. Glaucarubin can be used as an amœbicide for amebiasis research. Glaucarubin is well tolerated, with LD₅₀s of 1,600 mg/kg for mice and 6,400 mg/kg for rats.