PARP7-IN-25
PARP7-IN-25 is a PARP7 inhibitor with an IC50 of 1.582 nM.PARP7-IN-25 inhibits enzymatic activity of PARP7. PARP7-IN-25 inhibits proliferation of lung cancer cells.PARP7-IN-25 can be used for the research of PARP7-related cancer.
For research use only. We do not sell to patients.
- CAS No.: 2819998-77-9
- Formula: C23H23F6N5O4
- Molecular Weight:547.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP7 1.582 nM (IC50) |
PARP7-IN-25 (compound I) (0.08-50 nM; 15 min pre-incubation, 3 h final incubation at 25°C) potently inhibits recombinant PARP7 enzyme activity with an IC50 of 1.582 nM[1].
PARP7-IN-25 (144 h) potently inhibits the proliferation of PARP7-overexpressing H1373 lung cancer cells with an IC50 of 13.012 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2819998-77-9
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Molecular Weight 547.45
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Formula C23H23F6N5O4
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SMILES
CC1=C2N(CCN(C2)C(CCOC[C@H](C)OC3=C(C(NN=C3)=O)C(F)(F)F)=O)C4=NC=C(C(F)(F)F)C=C41
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP7-IN-25 Related Classifications
HY-179312 Related Classifications
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