2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP7-IN-25

PARP7-IN-25 is a PARP7 inhibitor with an IC50 of 1.582 nM.PARP7-IN-25 inhibits enzymatic activity of PARP7. PARP7-IN-25 inhibits proliferation of lung cancer cells.PARP7-IN-25 can be used for the research of PARP7-related cancer.

For research use only. We do not sell to patients.

PARP7-IN-25

PARP7-IN-25 Chemical Structure

CAS No. : 2819998-77-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PARP7-IN-25 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PARP7-IN-25 is a PARP7 inhibitor with an IC50 of 1.582 nM.PARP7-IN-25 inhibits enzymatic activity of PARP7. PARP7-IN-25 inhibits proliferation of lung cancer cells.PARP7-IN-25 can be used for the research of PARP7-related cancer[1].

IC50 & Target[1]

PARP7

1.582 nM (IC50)

In Vitro

PARP7-IN-25 (compound I) (0.08-50 nM; 15 min pre-incubation, 3 h final incubation at 25°C) potently inhibits recombinant PARP7 enzyme activity with an IC50 of 1.582 nM[1].
PARP7-IN-25 (144 h) potently inhibits the proliferation of PARP7-overexpressing H1373 lung cancer cells with an IC50 of 13.012 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP7-IN-25 Related Antibodies
Molecular Weight

547.45

Formula

C23H23F6N5O4
CAS No.
SMILES

CC1=C2N(CCN(C2)C(CCOC[C@H](C)OC3=C(C(NN=C3)=O)C(F)(F)F)=O)C4=NC=C(C(F)(F)F)C=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PARP7-IN-25 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP7-IN-252819998-77-9PARPpoly ADP ribose polymeraselung cancer cellsPARP7recombinant PARP7 enzymeH1373 lung cancer cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PARP7-IN-25
Cat. No.:
HY-179312
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.