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Referencia número: HY-190257

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PDE3A/B-IN-1

PDE3A/B-IN-1 (Example 12) is a PDE3A/B molecular glue inhibitor. PDE3A/B-IN-1 inhibits tumor cell proliferation by inducing and stabilizing the formation of a complex between PDE3A/B and SLFN12 protein. PDE3A/B-IN-1 can be used for cancer research.

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No. CAS: 2275773-39-0
Fòrmula: C₁₅H₁₃N₃O₃
Peso molecular:283.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

PDE3A/B-IN-1 Chemical Structure

No. CAS: 2275773-39-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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^[1]

PDE3A

PDE3B

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

In Vitro

Molecular glues are a class of small-molecule compounds that induce or stabilize novel protein-protein interactions (PPIs) between proteins that inherently lack natural affinity within cells. By remodeling the spatial topology of protein complexes, molecular glues achieve functional regulation of target proteins, structural stabilization, or specific degradation dependent on the ubiquitin-proteasome system.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 2275773-39-0
Peso molecular 283.28
Fòrmula C₁₅H₁₃N₃O₃
SMILES

CC1=C(C2=CNC(C=C2)=O)C=CC(C3=NNC(OC3)=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Manuel Ellermann, et al. PDE3A-SLFN12 complex inducers for cancer treatment. WO2019025562A1. WIPO. 2019-02-07.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PDE3A/B-IN-1

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)

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